Physiological response of Simocephalus vetulus to five antibiotics and their mixture under 48-h acute exposure.

Autor: Nguyen TD; Graduate school of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Japan., Itayama T; Graduate school of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Japan. Electronic address: itayama@nagasaki-u.ac.jp., Ramaraj R; School of Renewable Energy, Maejo University, Sansai, Chiang Mai 50290, Thailand., Iwami N; School of Science and Engineering, Meise University, 2-1-1 Hodokubo, Hino-shi, Tokyo 191-8506, Japan., Shimizu K; Graduate School of Science and Technology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki, Japan., Dao TS; Faculty of Environment and Natural Resources, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Viet Nam; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Viet Nam., Pham TL; Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Street, Cau Giay District, Hanoi 100000, Viet Nam; Institute of Tropical Biology, Vietnam Academy of Science and Technology (VAST), 85 Tran Quoc Toan Street, District 3, Ho Chi Minh City 700000, Viet Nam., Maseda H; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2022 Jul 10; Vol. 829, pp. 154585. Date of Electronic Publication: 2022 Mar 16.
DOI: 10.1016/j.scitotenv.2022.154585
Abstrakt: Antibiotics, widely known as major environmental xenobiotics, are increasingly being released into ecosystems due to their essential functions in human health and production. During the COVID-19 pandemic waves, antibiotic use increases remarkably in treating bacterial coinfections. Antibiotics were initially expected only to affect prokaryotes, but recent research has shown that they can disturb the biological systems of eukaryotes, especially vulnerable aquatic creatures, through both direct and indirect processes. However, their toxicity to the freshwater cladoceran Simocephalus vetulus, an essential link in the aquatic food web, has never been evaluated. The effects of four fluoroquinolones (ciprofloxacin: CFX, ofloxacin: OFX, gatifloxacin: GFX, delafloxacin: DFX), tetracycline (TET), and a mixture of these medicines (MIX) on S. vetulus thoracic limb rate (TLR) were examined in this study. After S. vetulus was exposed to 20 and 40 mg GFX L -1 , 90% and 100% mortality rates were recorded. At 2.5-10 mg L -1 , GFX dramatically lowered the TLR of S. vetulus, resulting in a median effective concentration of 9.69 mg L -1 . TLRs increased when the organisms were exposed to 10-40 mg L -1 of CFX and 1.25-40 mg L -1 of OFX. However, DFX and TET exposures did not affect TLRs. Exposure to MIX reduced TLR only at 40 mg L -1 , suggesting an antagonistic interaction among the five pharmaceuticals. This study demonstrated that S. vetulus physiological responses to antibiotics, even in the same class, are complex and elusive. Beyond a common additive concentration principle, the antagonistic interaction of antibiotic mixture indicates a high level of uncertainty in terms of ecological dangers. We initially introduce S. vetulus to ecotoxicological studies of antibiotics, presenting the species as a low-cost model for physiological investigations of environmental xenobiotics.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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