Modulation of lymphocyte subpopulations in the small intestine of mice treated with probiotic bacterial strains and infected with Trichinella spiralis.

Autor: Dvorožňáková E; Institute of Parasitology, Slovak Academy of Sciences, Košice, Slovak Republic., Vargová M; Institute of Parasitology, Slovak Academy of Sciences, Košice, Slovak Republic.; University of Veterinary Medicine and Pharmacy in Košice, Košice, Slovak Republic., Hurníková Z; Institute of Parasitology, Slovak Academy of Sciences, Košice, Slovak Republic., Lauková A; Institute of Animal Physiology, Centre of Biosciences of the Slovak Academy of Sciences, Košice, Slovak Republic., Revajová V; University of Veterinary Medicine and Pharmacy in Košice, Košice, Slovak Republic.
Jazyk: angličtina
Zdroj: Journal of applied microbiology [J Appl Microbiol] 2022 Jun; Vol. 132 (6), pp. 4430-4439. Date of Electronic Publication: 2022 Mar 28.
DOI: 10.1111/jam.15534
Abstrakt: Aims: To study the local intestinal lymphocyte immunity in mice with trichinellosis affected by probiotic bacteria.
Methods and Results: Enterococcus faecium CCM8558, Enterococcus durans ED26E/7, Limosilactobacillus fermentum CCM7421 and Lactiplantibacillus plantarum 17 L/1 were administered daily (10 9  CFU ml -1 ) and mice were infected with Trichinella spiralis (400 larvae) on the 7th day of treatment. T. spiralis infection significantly inhibited lymphocyte subpopulations from 5 to 25 days postinfection (dpi). L. fermentum CCM7421 and L. plantarum 17 L/1 restored the CD4 + T cell numbers in the epithelium and lamina propria at the control level from 11 dpi. All strains stimulated the CD8 + T cells numbers in infected mice, which were restored in the lamina propria on 11 dpi and in the epithelium only on 32 dpi. B cells (CD19 + ) inhibition after T. spiralis infection was not affected by treatment till 25 dpi.
Conclusions: The strain-specific immunomodulatory effect of tested bacteria was confirmed. L. fermentum CCM7421 and L. plantarum 17 L/1 showed the greatest immunomodulatory potential on CD4 + and CD8 + T lymphocytes in trichinellosis. E. faecium CCM8558 and E. durans ED26E/7 activated only CD8 + T cells in the lamina propria.
Significance and Impact of the Study: Positive modulation of the gut lymphocyte immunity in T. spiralis infection with bacterial strains showed their beneficial effect with the host's antiparasitic defence.
(© 2022 Society for Applied Microbiology.)
Databáze: MEDLINE
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