ZIKV can infect human term placentas in the absence of maternal factors.

Autor: Villazana-Kretzer DL; Division of Maternal Fetal Medicine, Madigan Army Medical Center, Tacoma, WA, USA., Wuertz KM; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Newhouse D; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Damicis JR; Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA., Dornisch EM; Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA., Voss KM; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Muruato AE; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Paymaster JA; Division of Maternal Fetal Medicine, Madigan Army Medical Center, Tacoma, WA, USA., Schmiedecke SS; Division of Maternal Fetal Medicine, Madigan Army Medical Center, Tacoma, WA, USA., Edwards SM; Division of Maternal Fetal Medicine, Madigan Army Medical Center, Tacoma, WA, USA., Napolitano PG; Department of OB/GYN, University of Washington Medical Center, Seattle, WA, USA., Tisoncik-Go J; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Ieronimakis N; Division of Maternal Fetal Medicine, Madigan Army Medical Center, Tacoma, WA, USA. nicholas.m.ieronimakis.civ@mail.mil.; Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA. nicholas.m.ieronimakis.civ@mail.mil., Gale M Jr; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA. mgale@uw.edu.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2022 Mar 18; Vol. 5 (1), pp. 243. Date of Electronic Publication: 2022 Mar 18.
DOI: 10.1038/s42003-022-03158-6
Abstrakt: Zika virus infection can result in devastating pregnancy outcomes when it crosses the placental barrier. For human pregnancies, the mechanisms of vertical transmission remain enigmatic. Utilizing a human placenta-cotyledon perfusion model, we examined Zika virus exposure in the absence of maternal factors. To distinguish responses related to viral infection vs. recognition, we evaluated cotyledons perfused with either active or inactivated Zika virus. Active Zika virus exposure resulted in infection, cell death and syncytium injury. Pathology corresponded with transcriptional changes related to inflammation and innate immunity. Inactive Zika virus exposure also led to syncytium injury and related changes in gene expression but not cell death. Our observations reveal pathologies and innate immune responses that are dependent on infection or virus placenta interactions independent of productive infection. Importantly, our findings indicate that Zika virus can infect and compromise placentas in the absence of maternal humoral factors that may be protective.
(© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.)
Databáze: MEDLINE
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