Muscle wasting assessment tools for prostate cancer.

Autor: Espinosa-Marrón A; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Rubio-Blancas A; Universidad Autónoma de la Ciudad de México, Mexico City, Mexico., Quiñones-Capistran CA; Department of Nuclear Medicine, National Cancer Institute, Mexico City, Mexico., Camacho-Zamora A; National Institute of Public Health of Mexico, Cuernavaca, Morelos, Mexico., Salcedo-Grajales I; Division of Nutrition, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, Mexico., Bravo-García AP; Division of Nutrition, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, Mexico., Bourlon MT; Department of Hematology and Oncology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, Mexico., Castillejos-Molina RA; Department of Urology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, Mexico., Dias JA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Del Pilar Milke-García M; Division of Nutrition, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico City, Mexico. nutriclinica@hotmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Mar 18; Vol. 12 (1), pp. 4662. Date of Electronic Publication: 2022 Mar 18.
DOI: 10.1038/s41598-022-08501-9
Abstrakt: Prostate cancer and its treatment may induce muscle wasting. Body composition and muscle functionality are rarely assessed in patients with prostate cancer from developing countries due to the limited availability of high-quality equipment for routine diagnosis. This cross-sectional study evaluated the association between several simplistic techniques for assessing muscle mass and function with a more complex standard of reference for muscle wasting among Mexican men with prostate cancer. Muscle wasting was highly prevalent, yet it was presumably associated with aging rather than cancer and its treatment itself. The restricted availability of specific equipment in clinical settings with technological limitations supports using unsophisticated techniques as surrogate measurements for muscle wasting. The left-arm handgrip dynamometry displayed the highest correlation with the standard of reference and exhibited an acceptable predicted probability for muscle estimation. Combining several simplistic techniques may be preferable. We also developed and internally validated a manageable model that helps to identify elderly patients with prostate cancer at risk of muscle depletion and impairment. These findings promote the early recognition and treatment of muscle wasting alterations occurring among older adults with prostate cancer.
(© 2022. The Author(s).)
Databáze: MEDLINE
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