Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells.

Autor: Weber A; Goethe University, Department of Aquatic Ecotoxicology, Faculty of Biological Sciences, Max-von-Laue-Straße 13, 60438 Frankfurt am Main, Germany., Schwiebs A; Goethe University Hospital, Institute of General Pharmacology and Toxicology, pharmazentrum frankfurt, Theodor-Stern-Kai 7/75, 60596 Frankfurt am Main, Germany., Solhaug H; Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Erling Skjalgssons gate 1, Trondheim, Norway., Stenvik J; Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Erling Skjalgssons gate 1, Trondheim, Norway; Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, Olav Kyrres gate 17, Trondheim, Norway., Nilsen AM; Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Erling Skjalgssons gate 1, Trondheim, Norway., Wagner M; Norwegian University of Science and Technology, Department of Biology, Høgskoleringen 5, Realfagbygget, 7491 Trondheim, Norway. Electronic address: martin.wagner@ntnu.no., Relja B; Otto-von-Guericke University, Department of Radiology and Nuclear Medicine, Experimental Radiology, Leipziger Str. 44, 39120 Magdeburg, Germany., Radeke HH; Goethe University Hospital, Institute of General Pharmacology and Toxicology, pharmazentrum frankfurt, Theodor-Stern-Kai 7/75, 60596 Frankfurt am Main, Germany.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2022 May; Vol. 163, pp. 107173. Date of Electronic Publication: 2022 Mar 15.
DOI: 10.1016/j.envint.2022.107173
Abstrakt: So far, the human health impacts of nano- and microplastics are poorly understood. Thus, we investigated whether nanoplastics exposure induces inflammatory processes in primary human monocytes and monocyte-derived dendritic cells. We exposed these cells in vitro to nanoplastics of different shapes (irregular vs. spherical), sizes (50-310 nm and polydisperse mixtures) and polymer types (polystyrene; polymethyl methacrylate; polyvinyl chloride, PVC) using concentrations of 30-300 particles cell -1 . Our results show that irregular PVC particles induce the strongest cytokine release of these nanoplastics. Irregular polystyrene triggered a significantly higher pro-inflammatory response compared to spherical nanoplastics. The contribution of chemicals leaching from the particles was minor. The effects were concentration-dependent but varied markedly between cell donors. We conclude that nanoplastics exposure can provoke human immune cells to secrete cytokines as key initiators of inflammation. This response is specific to certain polymers (PVC) and particle shapes (fragments). Accordingly, nanoplastics cannot be considered one homogenous entity when assessing their health implications and the use of spherical polystyrene nanoplastics may underestimate their inflammatory effects.
(Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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