Current and Emerging Therapies for Limbal Stem Cell Deficiency.

Autor:	Elhusseiny AM; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Soleimani M; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA., Eleiwa TK; Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt., ElSheikh RH; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA., Frank CR; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA., Naderan M; Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Yazdanpanah G; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA., Rosenblatt MI; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA., Djalilian AR; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	Stem cells translational medicine [Stem Cells Transl Med] 2022 Mar 31; Vol. 11 (3), pp. 259-268.
DOI:	10.1093/stcltm/szab028
Abstrakt:	The corneal epithelium serves to protect the underlying cornea from the external environment and is essential for corneal transparency and optimal visual function. Regeneration of this epithelium is dependent on a population of stem cells residing in the basal layer of the limbus, the junction between the cornea and the sclera. The limbus provides the limbal epithelial stem cells (LESCs) with an optimal microenvironment, the limbal niche, which strictly regulates their proliferation and differentiation. Disturbances to the LESCs and/or their niche can lead to the pathologic condition known as limbal stem cell deficiency (LSCD) whereby the corneal epithelium is not generated effectively. This has deleterious effects on the corneal and visual function, due to impaired healing and secondary corneal opacification. In this concise review, we summarize the characteristics of LESCs and their niche, and present the current and future perspectives in the management of LSCD with an emphasis on restoring the function of the limbal niche. (© The Author(s) 2022. Published by Oxford University Press.)
Databáze:	MEDLINE
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