Effect of preoperative administration of atenolol to dogs with pulmonic stenosis undergoing interventional procedures.

Autor: Gomart S; Highcroft Veterinary Referrals, CVS Group, Bristol, United Kingdom., MacFarlane P; Langford Vets, University of Bristol, Bristol, United Kingdom., Payne JR; Langford Vets, University of Bristol, Bristol, United Kingdom., Hezzell MJ; Bristol Vet School, University of Bristol, Bristol, United Kingdom., Borgeat K; Langford Vets, University of Bristol, Bristol, United Kingdom.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2022 May; Vol. 36 (3), pp. 877-885. Date of Electronic Publication: 2022 Mar 18.
DOI: 10.1111/jvim.16403
Abstrakt: Background: Beta-blockade is sometimes used in dogs with pulmonic stenosis with the intent of reducing frequency of ventricular arrhythmias during right heart catheterization.
Objectives: To evaluate if pretreatment with atenolol reduces frequency of ventricular arrhythmias, anesthetist interventions, or shortens procedure time.
Animals: Thirty dogs with pulmonic stenosis scheduled for interventional procedures.
Methods: Single center, prospective, randomized, open-label study. Dogs were randomized to treatment with atenolol or no treatment preoperatively for a minimum of 10 days. Variables recorded included heart rate, arrhythmias and complexity, total procedure time and administration of antiarrhythmic treatment, vasopressors, positive chronotropes, or fluid boluses.
Results: Fifteen dogs were enrolled in each group. Dogs receiving atenolol had lower mean heart rates during the procedure (atenolol 100 ± 11 bpm vs untreated 115 ± 19 bpm, P = .01). There were no significant differences between the atenolol and untreated groups in the frequency of ventricular ectopic complexes (535 [6-5296] vs 553 [79-2863], P = .9), ventricular couplets (46 [0-481] vs 29 [3-121], P = .59), ventricular triplets (20 [0-265] vs 16 [1-82], P = .67), ventricular tachycardia (8 [0-224] vs 8 [1-118], P = .99), proportion exhibiting R-on-T phenomenon (11/15 vs 14/15, P = .33), proportion receiving intraoperative lidocaine (1/15 vs 3/15, P = .6), vasopressors/positive chronotropes (11/15 vs 5/15, P = .06), or fluid boluses (12/15 vs 7/15, P = .13). The procedure time was similar (atenolol 41 [23-68] min vs untreated 35 [18-98] min, P = .91).
Conclusions and Clinical Importance: No benefit of preoperative atenolol treatment was identified in this small group of dogs.
(© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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