Prognostic significance of laterality in lung neuroendocrine tumors.

Autor: La Salvia A; Department of Oncology, 12 de Octubre University Hospital, Madrid, Spain., Persano I; Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy., Siciliani A; Department of Thoracic Surgery, Sant'Andrea University Hospital, Rome, Italy., Verrico M; Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy., Bassi M; Department of Thoracic Surgery, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Modica R; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Audisio A; Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy., Zanata I; Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy., Trabalza Marinucci B; Department of Thoracic Surgery, Sant'Andrea University Hospital, Rome, Italy., Trevisi E; Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy., Puliani G; Oncological Endocrinology Unit, Regina Elena National Cancer Institute, Rome, Italy.; Department of Experimental Medicine, 'Sapienza' University of Roma, Rome, Italy., Rinzivillo M; Digestive Disease Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, Rome, Italy., Parlagreco E; Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy., Baldelli R; Endocrinology Unit, Department of Oncology and Medical Specialities, A.O. San Camillo-Forlanini, Rome, Italy., Feola T; Department of Experimental Medicine, 'Sapienza' University of Roma, Rome, Italy.; Neuroendocrinology, Neuromed Institute, IRCCS, Pozzilli, Italy., Sesti F; Department of Experimental Medicine, 'Sapienza' University of Roma, Rome, Italy., Razzore P; Endocrinology Unit, Mauriziano Hospital, Turin, Italy., Mazzilli R; Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, ENETS Center of Excellence, Rome, Italy., Mancini M; Division of Morphologic and Molecular, S. Andrea Hospital, Rome, Italy., Panzuto F; Digestive Disease Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, Rome, Italy., Volante M; Department of Oncology, Pathology Unit of San Luigi Hospital, University of Turin, Orbassano, Turin, Italy., Giannetta E; Department of Experimental Medicine, 'Sapienza' University of Roma, Rome, Italy., Romero C; Scientific Support, 12 de Octubre University Hospital, Madrid, Spain., Appetecchia M; Oncological Endocrinology Unit, Regina Elena National Cancer Institute, Rome, Italy., Isidori A; Department of Experimental Medicine, 'Sapienza' University of Roma, Rome, Italy., Venuta F; Department of Thoracic Surgery, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Ambrosio MR; Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy., Zatelli MC; Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy., Ibrahim M; Department of Thoracic Surgery, Sant'Andrea University Hospital, Rome, Italy., Colao A; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy., Brizzi MP; Department of Oncology, San Luigi Gonzaga Hospital, Orbassano, Italy., García-Carbonero R; Department of Oncology, 12 de Octubre University Hospital, Madrid, Spain., Faggiano A; Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, ENETS Center of Excellence, Rome, Italy. antongiulio.faggiano@uniroma1.it.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2022 Jun; Vol. 76 (3), pp. 733-746. Date of Electronic Publication: 2022 Mar 18.
DOI: 10.1007/s12020-022-03015-w
Abstrakt: Purpose: Well-differentiated lung neuroendocrine tumors (Lu-NET) are classified as typical (TC) and atypical (AC) carcinoids, based on mitotic counts and necrosis. However, prognostic factors, other than tumor node metastasis (TNM) stage and the histopathological diagnosis, are still lacking. The current study is aimed to identify potential prognostic factors to better stratify lung NET, thus, improving patients' treatment strategy and follow-up.
Methods: A multicentric retrospective study, including 300 Lung NET, all surgically removed, from Italian and Spanish Institutions.
Results: Median age 61 years (13-86), 37.7% were males, 25.0% were AC, 42.0% were located in the lung left parenchyma, 80.3% presented a TNM stage I-II. Mitotic count was ≥2 per 10 high-power field (HPF) in 24.7%, necrosis in 13.0%. Median overall survival (OS) was 46.1 months (0.6-323), median progression-free survival (PFS) was 36.0 months (0.3-323). Female sex correlated with a more indolent disease (T1; N0; lower Ki67; lower mitotic count and the absence of necrosis). Left-sided primary tumors were associated with higher mitotic count and necrosis. At Cox-multivariate regression model, age, left-sided tumors, nodal (N) positive status and the diagnosis of AC resulted independent negative prognostic factors for PFS and OS.
Conclusions: This study highlights that laterality is an independent prognostic factors in Lu-NETs, with left tumors being less frequent but showing a worse prognosis than right ones. A wider spectrum of clinical and pathological prognostic factors, including TNM stage, age and laterality is suggested. These parameters could help clinicians to personalize the management of Lu-NET.
(© 2022. The Author(s).)
Databáze: MEDLINE
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