The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer's Development.

Autor: Nguyen TT; Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, 700000, Vietnam., Hulme J; Department of BioNano Technology, Gachon University, Seongnam, 461-701, Republic of Korea. johnhulme21@gmail.com., Vo TK; Vietnam Sports Hospital, Ministry of Culture, Sports and Tourism, Hanoi, 100000, Vietnam.; Department of Sports Medicine, University of Medicine and Pharmacy (VNU-UMP), Vietnam National University Hanoi, Hanoi, 100000, Vietnam., Van Vo G; Department of Biomedical Engineering, School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. vvgiau@medvnu.edu.vn.; Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. vvgiau@medvnu.edu.vn.; Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000, Vietnam. vvgiau@medvnu.edu.vn.
Jazyk: angličtina
Zdroj: Neurochemical research [Neurochem Res] 2022 Jun; Vol. 47 (6), pp. 1503-1512. Date of Electronic Publication: 2022 Mar 17.
DOI: 10.1007/s11064-022-03569-1
Abstrakt: The bidirectional communication between the brain and peripheral organs have been widely documented, but the impact of visceral adipose tissue (VAT) dysfunction and its relation to structural and functional brain changes have yet to be fully elucidated. This review initially examines the clinical evidence supporting associations between the brain and VAT before visiting the roles of the autonomic nervous system, fat and glucose metabolism, neuroinflammation, and metabolites. Finally, the possible effects and potential mechanisms of the brain-VAT axis on the pathogenesis of Alzheimer's disease are discussed, providing new insights regarding future prevention and therapeutic strategies.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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