Effects of different physical training protocols on inflammatory markers in Zymosan-induced rheumatoid arthritis in Wistar rats.

Autor: Damasceno de Lima R; Graduate Program in Biomedical Sciences, Centro Universitário Hermínio Ometto-UNIARARAS, Araras, São Paulo, Brazil., Pedersen M; Graduate Program in Biomedical Sciences, Centro Universitário Hermínio Ometto-UNIARARAS, Araras, São Paulo, Brazil., Costa do Bomfim FR; Graduate Program in Biomedical Sciences, Centro Universitário Hermínio Ometto-UNIARARAS, Araras, São Paulo, Brazil., Chiarotto GB; Graduate Program in Biomedical Sciences, Centro Universitário Hermínio Ometto-UNIARARAS, Araras, São Paulo, Brazil., Canciglieri PH; Hermínio Ometto University Center-UNIARARAS, Araras, São Paulo, Brazil., Pauli JR; Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.; OCRC-Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Felonato M; Graduate Program in Biomedical Sciences, Centro Universitário Hermínio Ometto-UNIARARAS, Araras, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Cell biochemistry and function [Cell Biochem Funct] 2022 Apr; Vol. 40 (3), pp. 321-332. Date of Electronic Publication: 2022 Mar 17.
DOI: 10.1002/cbf.3697
Abstrakt: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and involvement of the synovial membrane, causing joint damage and deformities. No effective drug treatment is available, and physical exercise has been utilized to alleviate the inflammatory processes. This study aimed to investigate the effects of different exercise training protocols on Zymosan-induced RA inflammatory markers in the right knee of Wistar rats. The rodents were subjected to aerobic, resisted, and combined physical training protocols with variations in the total training volume (50% or 100% of resistance and aerobic training volume) for 8 weeks. All physical training protocols reduced cachexia and systemic inflammatory processes. The histological results showed an increase in the inflammatory influx to the synovial tissue of the right knee in all physical training protocols. The rats that underwent combined physical training with reduced volume had a lower inflammatory influx compared to the other experimental groups. A reduction in the mRNA expression of inflammatory genes and an increase in anti-inflammatory gene expression were also observed. The physical training protocol associated with volume reduction attenuated systemic and synovial inflammation of the right knee, reducing the impact of Zymosan-induced RA in rats.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: