A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth.

Autor: Tricò D; Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa., Galderisi A; Hopital Necker-Enfants Malades, Paris, France., Van Name MA; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Caprio S; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Samuels S; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Li Z; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Galuppo BT; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Savoye M; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Mari A; Institute of Neuroscience, National Research Council, Padua, Italy., Feldstein AE; Department of Pediatrics, University of California San Diego, San Diego, California, USA., Santoro N; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Medicine and Health Sciences, 'V.Tiberio' University of Molise, Campobasso, Italy.
Jazyk: angličtina
Zdroj: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2022 Jul; Vol. 24 (7), pp. 1267-1276. Date of Electronic Publication: 2022 Apr 18.
DOI: 10.1111/dom.14695
Abstrakt: Aim: To examine the determinants and metabolic impact of the reduction in fasting and postload insulin levels after a low n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio diet in obese youth.
Materials and Methods: Insulin secretion and clearance were assessed by measuring and modelling plasma insulin and C-peptide in 17 obese youth who underwent a nine-point, 180-minute oral glucose tolerance test (OGTT) before and after a 12-week, eucaloric low n-6:n-3 polyunsaturated fatty acid (PUFA) ratio diet. Hepatic fat content was assessed by repeated abdominal magnetic resonance imaging.
Results: Insulin clearance at fasting and during the OGTT was significantly increased after the diet, while body weight, glucose levels, absolute and glucose-dependent insulin secretion, and model-derived variables of β-cell function were not affected. Dietary-induced changes in insulin clearance positively correlated with changes in whole-body insulin sensitivity and β-cell glucose sensitivity, but not with changes in hepatic fat. Subjects with greater increases in insulin clearance showed a worse metabolic profile at enrolment, characterized by impaired insulin clearance, β-cell glucose sensitivity, and glucose tolerance, and benefitted the most from the diet, achieving greater improvements in glucose-stimulated hyperinsulinaemia, insulin resistance, and β-cell function.
Conclusions: We showed that a 12-week low n-6:n-3 PUFA ratio diet improves hyperinsulinaemia by increasing fasting and postload insulin clearance in obese youth, independently of weight loss, glucose concentrations, and insulin secretion.
(© 2022 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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