MAPK activation drives male and female mouse teratocarcinomas from late primordial germ cells.

Autor:	Guida E; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Tassinari V; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Colopi A; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Todaro F; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Cesarini V; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Jannini B; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Pellegrini M; Institute of Biochemistry and Cell Biology, IBBC-CNR, Monterotondo, Rome, Italy., Botti F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.; Pathology Department, S. Eugenio Hospital, Rome, Italy., Rossi G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Rossi P; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Jannini EA; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Dolci S; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Journal of cell science [J Cell Sci] 2022 Apr 15; Vol. 135 (8). Date of Electronic Publication: 2022 Apr 20.
DOI:	10.1242/jcs.259375
Abstrakt:	Germ cell tumors (GCTs) are rare tumors that can develop in both sexes, peaking in adolescents. To understand the mechanisms that underlie germ cell transformation, we established a GCT mouse model carrying a germ-cell-specific BRafV600E mutation with or without heterozygous Pten deletion. Both male and female mice developed monolateral teratocarcinomas containing embryonal carcinoma (EC) cells that showed an aggressive phenotype and metastatic ability. Germ cell transformation started in fetal gonads and progressed after birth leading to gonadal invasion. Early postnatal testes showed foci of tumor transformation, whereas ovaries showed increased number of follicles, multi-ovular follicles (MOFs) and scattered metaphase I oocytes containing follicles. Our results indicate that MAPK (herein referring to Erk1/2) overactivation in fetal germ cells of both sexes can expand their proliferative window leading to neoplastic transformation and metastatic behavior. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2022. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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