Frequency Dependent Electrical Stimulation of PFC and ACC for Acute Pain Treatment in Rats.

Autor:	Liu Y; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States., Xu H; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States., Sun G; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States.; Interdisciplinary Pain Research Program, New York University Langone Health, New York, NY, United States.; Department of Psychiatry, New York University School of Medicine, New York, NY, United States., Vemulapalli B; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States., Jee HJ; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States., Zhang Q; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States.; Interdisciplinary Pain Research Program, New York University Langone Health, New York, NY, United States., Wang J; Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, United States.; Interdisciplinary Pain Research Program, New York University Langone Health, New York, NY, United States.; Department of Neuroscience & Physiology, New York University School of Medicine, New York, NY, United States.; Neuroscience Institute, New York University School of Medicine, New York, NY, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in pain research (Lausanne, Switzerland) [Front Pain Res (Lausanne)] 2021 Aug 27; Vol. 2, pp. 728045. Date of Electronic Publication: 2021 Aug 27 (Print Publication: 2021).
DOI:	10.3389/fpain.2021.728045
Abstrakt:	As pain consists of both sensory and affective components, its management by pharmaceutical agents remains difficult. Alternative forms of neuromodulation, such as electrical stimulation, have been studied in recent years as potential pain treatment options. Although electrical stimulation of the brain has shown promise, more research into stimulation frequency and targets is required to support its clinical applications. Here, we studied the effect that stimulation frequency has on pain modulation in the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC) in acute pain models in rats. We found that low-frequency stimulation in the prelimbic region of the PFC (PL-PFC) provides reduction of sensory and affective pain components. Meanwhile, high-frequency stimulation of the ACC, a region involved in processing pain affect, reduces pain aversive behaviors. Our results demonstrate that frequency-dependent neuromodulation of the PFC or ACC has the potential for pain modulation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Liu, Xu, Sun, Vemulapalli, Jee, Zhang and Wang.)
Databáze:	MEDLINE
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