Sex-specific Associations Between Type 2 Diabetes Incidence and Exposure to Dioxin and Dioxin-like Pollutants: A Meta-analysis.

Autor:	Gang N; Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, ON, Canada., Van Allen K; Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, ON, Canada., Villeneuve PJ; School of Mathematics and Statistics, Carleton University, Ottawa, ON, Canada.; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada., MacDonald H; Health and Biosciences Librarian, MacOdrum Library, Carleton University, Ottawa, ON, Canada., Bruin JE; Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in toxicology [Front Toxicol] 2022 Feb 23; Vol. 3, pp. 685840. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2021).
DOI:	10.3389/ftox.2021.685840
Abstrakt:	The potential for persistent organic pollutants (POPs), including dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs), to increase the risk of incident diabetes in adults has been extensively studied. However, there is substantial variability in the reported associations both between and within studies. Emerging data from rodent studies suggest that dioxin disrupts glucose homeostasis in a sex-specific manner. Thus, we performed a review and meta-analysis of relevant epidemiological studies to investigate sex differences in associations between dioxin or DL-PCB exposure and type 2 diabetes incidence. Articles that met our selection criteria (n = 81) were organized into the following subcategories: data stratified by sex (n = 13), unstratified data (n = 45), and data from only 1 sex (n = 13 male, n = 10 female). We also considered whether exposure occurred either abruptly at high concentrations through a contamination event ("disaster exposure") or chronically at low concentrations ("non-disaster exposure"). There were 8 studies that compared associations between dioxin/DL-PCB exposure and diabetes risk in males versus females within the same population. When all sex-stratified or single-sex studies were considered in the meta-analysis (n = 18), the summary relative risk (RR) for incident diabetes among those exposed relative to reference populations was 1.78 (95% CI = 1.37-2.31) and 1.95 (95% CI = 1.56-2.43) for female and males, respectively. However, when we restricted the meta-analysis to disaster-exposed populations, the RR was higher in females than males (2.86 versus 1.59, respectively). In contrast, in non-disaster exposed populations the RR for females was lower than males (1.40 and 2.02, respectively). Our meta-analysis suggests that there are sex differences in the associations between dioxin/DL-PCBs exposure and incident diabetes, and that the mode of exposure modifies these differences. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Gang, Van Allen, Villeneuve, MacDonald and Bruin.)
Databáze:	MEDLINE
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