Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects.
| Autor: | Laine L; Yale School of Medicine, New Haven, Connecticut, USA.; VA Connecticut Healthcare System, West Haven, Connecticut, USA., Sharma P; Veterans Affairs Medical Center and University of Kansas School of Medicine, Kansas City, Kansas, USA., Mulford DJ; Phathom Pharmaceuticals, Buffalo Grove, Illinois, USA., Hunt B; Phathom Pharmaceuticals, Buffalo Grove, Illinois, USA., Leifke E; Phathom Pharmaceuticals, Buffalo Grove, Illinois, USA., Smith N; Phathom Pharmaceuticals, Buffalo Grove, Illinois, USA., Howden CW; University of Tennessee College of Medicine, Memphis, Tennessee, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of gastroenterology [Am J Gastroenterol] 2022 Jul 01; Vol. 117 (7), pp. 1158-1161. Date of Electronic Publication: 2022 Mar 16. |
| DOI: | 10.14309/ajg.0000000000001735 |
| Abstrakt: | Introduction: We assessed pharmacodynamics and pharmacokinetics of a potassium-competitive acid blocker and proton pump inhibitor in US subjects. Methods: Healthy adults were randomized to 7-day periods of vonoprazan 20 mg once daily followed by lansoprazole 30 mg once daily or the reverse order, separated by ≥ 7 days of washout. Results: Vonoprazan (N = 40) had higher proportions of 24-hour periods with intragastric pH > 4 than lansoprazole (N = 41,38) on day 1 (62.4% vs 22.6%, P < 0.0001) and day 7 (87.8% vs 42.3%, P < 0.0001). Separation in pH started ∼2.5 hours after the first dose. Discussion: Vonoprazan provided more rapid and potent inhibition of intragastric acidity than lansoprazole in US subjects. (Copyright © 2022 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a "work of the United States Government" for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.) |
| Databáze: | MEDLINE |
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