Chronic rhinosinusitis with nasal polyps: how to identify eligible patients for biologics in clinical practice.

Autor:	Gelardi M; Department of Otolaryngology, University of Foggia, Italy., Bocciolini C; UOC of Otolaryngology Hospital Maggiore of Bologna, Italy., Notargiacomo M; Otorhinolaryngology Unit, Melzo Hospital, Milan, Italy., Schiavetti I; Epidemiology, Biostatistics and Committe, Department of Direction, Istituto Giannina Gaslini, Genoa, Italy., Lingua C; Otorhinolaryngology SC, ASO S, Croce and Carle, Cuneo, Italy., Pecoraro P; ORL - Asp 6, Palermo, Italy., Iannuzzi L; ENT Clinic, Department of Biomedical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy., Quaranta VA; Pneumology Unity, Di Venere Hospital, Bari, Italy., Giancaspro R; Department of Otolaryngology, University of Foggia, Italy., Ronca G; Department of Otolaryngology, University of Foggia, Italy., Cassano M; Department of Otolaryngology, University of Foggia, Italy., Ciprandi G; Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
Jazyk:	angličtina
Zdroj:	Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale [Acta Otorhinolaryngol Ital] 2022 Feb; Vol. 42 (1), pp. 75-81.
DOI:	10.14639/0392-100X-N1699
Abstrakt:	Objective: This study compared three severity measures for chronic rhinosinusitis with nasal polyps (CRSwNP). The outcome was to identify patients who are eligible for biological therapy. Methods: 330 adult patients with CRSwNP were examined. Nasal polyp score (NPS), sinonasal outcome test (SNOT-22) and clinical-cytological grading (CCG) were compared. Clinical history, past surgery and asthma control test were also considered. Results: Only 45 (13.6%) patients had a contextual positivity to the three severity measures. The concordance among tests was slight/fair. Patients with severe disease (all tests positive) had more impaired parameters. The mixed cytotype (OR = 4.07), nasal obstruction (OR = 10.06), post-nasal drip (OR = 1.98), embarrassment (OR = 2.53) and difficulty falling asleep (OR = 1.92) were significantly associated with severe CRSwNP. Conclusions: To identify candidates for biological therapy, the contextual use of NPS, SNOT-22 and CCG is preferable. In this way, global assessment of CRSwNP, including morphology, inflammation, comorbidity, symptoms and quality of life is possible. (Copyright © 2022 Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy.)
Databáze:	MEDLINE
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