An analysis of views about supported reduction or discontinuation of antipsychotic treatment among people with schizophrenia and other psychotic disorders.

Autor: Crellin NE; Research & Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, IG3 8XJ, UK. n.crellin@ucl.ac.uk.; Division of Psychiatry, University College London, London, W1T 7NF, UK. n.crellin@ucl.ac.uk., Priebe S; Unit for Social and Community Psychiatry, Queen Mary University of London, London, E1 4NS, UK., Morant N; Division of Psychiatry, University College London, London, W1T 7NF, UK., Lewis G; Division of Psychiatry, University College London, London, W1T 7NF, UK., Freemantle N; Institute of Clinical Trials and Methodology, University College London, London, WC1V 6LJ, UK., Johnson S; Division of Psychiatry, University College London, London, W1T 7NF, UK., Horne R; School of Pharmacy, University College London, London, WC1N 1AX, UK., Pinfold V; The McPin Foundation, London, SE1 4YR, UK., Kent L; Independent consultant, London, UK., Smith R; Independent consultant, London, UK., Darton K; Independent consultant, London, UK., Cooper RE; Unit for Social and Community Psychiatry, Queen Mary University of London, London, E1 4NS, UK.; University of Greenwich, Faculty of Education, Health and Human Sciences, London, SE10 9LS, UK.; East London NHS Foundation Trust, Newham Centre for Mental Health, London, E13 8SP, UK., Long M; Research & Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, IG3 8XJ, UK.; Division of Psychiatry, University College London, London, W1T 7NF, UK., Thompson J; Faculty of Medical Sciences, University College London, London, UK., Gruenwald L; Research & Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, IG3 8XJ, UK.; Division of Psychiatry, University College London, London, W1T 7NF, UK., Freudenthal R; Barnet Enfield Haringey Mental Health NHS Trust, London, UK., Stansfeld JL; Research & Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, IG3 8XJ, UK.; Division of Psychiatry, University College London, London, W1T 7NF, UK., Moncrieff J; Research & Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, IG3 8XJ, UK.; Division of Psychiatry, University College London, London, W1T 7NF, UK.
Jazyk: angličtina
Zdroj: BMC psychiatry [BMC Psychiatry] 2022 Mar 15; Vol. 22 (1), pp. 185. Date of Electronic Publication: 2022 Mar 15.
DOI: 10.1186/s12888-022-03822-5
Abstrakt: Background: Antipsychotic medication can reduce psychotic symptoms and risk of relapse in people with schizophrenia and related disorders, but it is not always effective and adverse effects can be significant. We know little of patients' views about continuing or discontinuing antipsychotic treatment.
Aims: To explore the views of people with schizophrenia and other psychotic disorders about continuing their antipsychotic medication or attempting to reduce or discontinue this medication with clinical support.
Methods: We collected quantitative and qualitative data by conducting semi-structured interviews in London, UK. Factors predicting a desire to discontinue medication were explored. Content analysis of qualitative data was undertaken.
Results: We interviewed 269 participants. 33% (95% CI, 27 to 39%) were content with taking long-term antipsychotic medication. Others reported they took it reluctantly (19%), accepted it on a temporary basis (24%) or actively disliked it (18%). 31% (95% CI, 25 to 37%) said they would like to try to stop medication with professional support, and 45% (95% CI, 39 to 51%) wanted the opportunity to reduce medication. People who wanted to discontinue had more negative attitudes towards the medication but were otherwise similar to other participants. Wanting to stop or reduce medication was motivated mainly by adverse effects and health concerns. Professional support was identified as potentially helpful to achieve reduction.
Conclusions: This large study reveals that patients are commonly unhappy about the idea of taking antipsychotics on a continuing or life-long basis. Professional support for people who want to try to reduce or stop medication is valued.
(© 2022. The Author(s).)
Databáze: MEDLINE
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