The role of platelet-rich plasma in the mild and severe stages of atherosclerotic disease in mice.

Autor:	da Silva LQ; Haemostasis Laboratory, Hemocentro - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-878, Brazil., Silva Justo-Junior AD; Department of Clinical Pathology, Faculty of Medical Sciences - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-970, Brazil., Moraes Martinelli B; Haemostasis Laboratory, Hemocentro - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-878, Brazil., da Cruz MA; Haemostasis Laboratory, Hemocentro - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-878, Brazil., Huber SC; Haemostasis Laboratory, Hemocentro - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-878, Brazil., de Lima Montalvão SA; Haemostasis Laboratory, Hemocentro - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-878, Brazil., de Freitas Filho LH; Laboratory of Atherosclerosis, Thrombosis & Cell Therapy, Institute of Biology Pathology - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-862, Brazil., Vicente CP; Laboratory of Atherosclerosis, Thrombosis & Cell Therapy, Institute of Biology Pathology - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-862, Brazil., Annichino-Bizzacchi JM; Haemostasis Laboratory, Hemocentro - State University of Campinas, UNICAMP. Campinas, São Paulo, 13083-878, Brazil.
Jazyk:	angličtina
Zdroj:	Regenerative medicine [Regen Med] 2022 May; Vol. 17 (5), pp. 259-270. Date of Electronic Publication: 2022 Mar 16.
DOI:	10.2217/rme-2021-0151
Abstrakt:	Background: Platelet-rich plasma (PRP) has a high concentration of growth factors (GFs), which present a therapeutic wound healing effect. Despite having been correlated with an immunomodulatory function, the administration of PRP has not yet been investigated in atherosclerosis models. Aim: Evaluate the effect of lyophilized PRP on atherosclerosis in mice models through serum analysis. Methods: Animals received a high-fat diet for disease induction and a weekly PRP retro-orbital application. Effectiveness was evaluated by measuring inflammatory markers in plasma following the treatment of mice with either PRP or saline solution. Results: PRP was well characterized for platelet and GF concentrations; the atherosclerotic profile was established. Cytokine concentrations were altered after PRP applications. Conclusion: PRP could modulate the inflammatory pattern in the early stages of atherosclerosis.
Databáze:	MEDLINE
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