Potential impact of serpin peptidase inhibitor clade (A) member 4 SERPINA4 (rs2093266) and SERPINA5 (rs1955656) genetic variants on COVID-19 induced acute kidney injury.

Autor: El-Hefnawy SM; Medical Biochemistry & Molecular Biology Department, Menoufia Faculty of Medicine, Egypt., Kasemy ZA; Public Health and Community Medicine, Menoufia Faculty of Medicine, Egypt., Eid HA; Chest Diseases and Tuberculosis Department, Menoufia Faculty of Medicine, Egypt., Elmadbouh I; Medical Biochemistry & Molecular Biology Department, Menoufia Faculty of Medicine, Egypt., Mostafa RG; Medical Microbiology and Immunology Department, Menoufia Faculty of Medicine, Egypt., Omar TA; Clinical Pathology Department, Menoufia Faculty of Medicine, Egypt., Kasem HE; Internal Medicine Departments, Faculty of Medicine, Menoufia University, Egypt., Ghonaim EM; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Egypt., Ghonaim MM; Medical Student, Faculty of Medicine, Menoufia University, Egypt., Saleh AA; Medical Biochemistry & Molecular Biology Department, Menoufia Faculty of Medicine, Egypt.; Medical Surgical Nursing Department, College of Nursing, Taibah University, Madina, Saudi Arabia.
Jazyk: angličtina
Zdroj: Human gene (Amsterdam, Netherlands) 2022 May; Vol. 32, pp. 101023. Date of Electronic Publication: 2022 May 09.
DOI: 10.1016/j.mgene.2022.101023
Abstrakt: Background: SARS-CoV-2 has a number of targets, including the kidneys. Acute Kidney Injury (AKI) might develop in up to a quarter of SARS-CoV-2 patients. In the clinical environment, AKI is linked to a high rate of death and leads to the progression of AKI to chronic renal disease.
Aim: We aimed to investigate rs2093266 and rs1955656 polymorphisms in SERPINA4 and SERPINA5 genes, respectively, as risk factors for COVID-19 induced AKI.
Subjects and Methods: A case-control study included 227 participants who were divided into three groups: 81 healthy volunteers who served as controls, 76 COVID-19 patients without AKI and 70 COVID -19 patients with AKI. The TaqMan assay was used for genotyping the SERPINA4 (rs2093266) and SERPINA5 (rs1955656) polymorphisms by real-time PCR technique.
Results: Lymphocytes and eGFR showed a significantly decreasing trend across the three studied groups, while CRP, d-Dimer, ferritin, creatinine, KIM-1and NGAL showed a significantly increasing trend across the three studied groups ( P  < 0.001). Rs2093266 (AG and AA) genotypes were significant risk factors among non-AKI and AKI groups in comparison to controls. Rs1955656 (AG and AA) were significant risk factors among the AKI group, while AA was the only significant risk factor among the non-AKI group. Recessive, dominant, co-dominant, and over-dominant models for genotype combinations were demonstrated. The GG v AA, GG + AG v AA, and GG v AG + AA models of the rs2093266 were all significant predictors of AKI, whilst only the GG v AA model of the rs1955656 SNP was a significant predictor. The logistic regression model was statistically significant, χ 2 = 56.48, p  < 0.001. AKI was associated with progressed age (OR = 0.95, 95% CI: 0.91-0.98, p  = 0.006), suffering from chronic diseases (OR = 3.25, 95% CI: 1.31-8.01, p  = 0.010), increased BMI (OR = 0.89, 95% CI: 0.81-0.98, p  = 0.018), immunosuppressive (OR = 4.61, 95% CI: 1.24-17.16, p  = 0.022) and rs2093266 (AG + AA) (OR = 3.0, 95% CI: 1.11-8.10, p  = 0.030).
Conclusion: Single nucleotide polymorphisms (rs2093266) at SERPINA4 gene and (rs1955656) at SERPINA5 gene were strongly linked to the development of AKI in COVID-19 patients.
Competing Interests: There is no conflict of interest among authors.
(© 2022 Published by Elsevier B.V.)
Databáze: MEDLINE
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