Reliable cognitive change following unilateral deep brain stimulation in essential tremor.

Autor:	Kielb S; Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Speelman C; Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Boxley L; Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Aase D; Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Dawson E; Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Changizi B; Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Merola A; Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Krishna V; University of North Carolina Hospitals, Chapel Hill, NC, USA., Nguyen C; Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jazyk:	angličtina
Zdroj:	Applied neuropsychology. Adult [Appl Neuropsychol Adult] 2024 Jul-Aug; Vol. 31 (4), pp. 601-605. Date of Electronic Publication: 2022 Mar 15.
DOI:	10.1080/23279095.2022.2048303
Abstrakt:	Objective: This retrospective analysis assessed regression-based reliable change (RC) of cognition in a sample of essential tremor (ET) patients who underwent unilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM-DBS). Method: Thirty patients (mean age at pre-evaluation = 70.4 ± 6.3 years) underwent neuropsychological evaluation pre- and post-unilateral VIM-DBS placement (mean time between pre and post-evaluation = 13.1 ± 4.0 months). Paired samples t -tests and RC analyses were employed. Results: No significant within-group differences were observed when cognitive scores were compared between evaluations. The vast majority of patients demonstrated stability across pre-and post-surgical evaluations (i.e. 29 out of 30); however, those with high-risk co-morbid medical conditions may be vulnerable to post-surgical cognitive decline as indicated by RC measures. Conclusions: The use of regression-based RC indices to assess individual cognitive changes between pre and post-surgical evaluations control for systematic and measurement errors that can occur over repeated evaluations, and may be able to identify cognitive changes that evade detection in traditional within-group comparisons.
Databáze:	MEDLINE
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