Carotid artery dissection in Hutchinson-Gilford Progeria: a case report.

Autor: González-Maestro V; Radiology Department, Complexo Hospitalario Universitario de Ferrol, Sergas, Spain. victor_maceda@hotmail.com., Monteagudo-Vilavedra E; Paediatrics Department, Complexo Hospitalario Universitario de Ferrol, Sergas, Spain., Rodríguez-Antuña J; Radiology Department, Complexo Hospitalario Universitario de Ferrol, Sergas, Spain., Lendoiro-Fuentes M; Paediatrics Department, Complexo Hospitalario Universitario de Ferrol, Sergas, Spain., Gómez MSB; Radiology Department, Complexo Hospitalario Universitario de Ferrol, Sergas, Spain., Miño EM; Paediatrics Department, Complexo Hospitalario Universitario de Ferrol, Sergas, Spain.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2022 Mar 14; Vol. 22 (1), pp. 135. Date of Electronic Publication: 2022 Mar 14.
DOI: 10.1186/s12887-022-03179-4
Abstrakt: Background: Strokes in the paediatric age group have their own epidemiology and aetiology and are frequently misdiagnosed. As in the adult population, they present some risk factors that must be identified. Cerebral arteriopathies as a cause of paediatric ischaemic stroke present a very diverse aetiology and morphology. In this article we report a paediatric stroke in a patient who was diagnosed during his first months of life of Hutchinson-Gilford´s Progeria (HGP). This is a rare genetic condition caused by mutations in the LMNA gene, producing an aberrant lamin A protein. The disease leads to premature aging, and cardiovascular complications are the first cause of morbidity and mortality in these patients.
Case Presentation: We report the case of a 5-year-old patient with HGP (missense mutation-de novo-c.1822G > A in heterozygosis, LMNA gene). The patient was diagnosed during his first year of life and presented distinct phenotypical features. No other relevant comorbidities were present. He was admitted to the emergency department for right hemiparesis with at least 4 h of evolution, with inability to open the hand and slight decrease in the level of consciousness (pedNIHSS 5-6). Cranial-CT and angio-CT showed findings indicative of left carotid dissection. Consensus was reached on conservative medical management with anticoagulation and antiplatelet therapy. In the first few days, the patient had a favourable evolution with resolution of the right lower limb hemiparesis and, one month after discharge, of the hand paresis.
Conclusions: The clinical manifestations, the vascular phenotype of the genetic mutation and the location of the radiological signs on a specific vascular morphology are indicative of carotid dissection. Spontaneous dissections occur under a predisposing risk factor or disease and are an exceptional finding in patients with HGP.
(© 2022. The Author(s).)
Databáze: MEDLINE
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