Salivary bacterial signatures in depression-obesity comorbidity are associated with neurotransmitters and neuroactive dipeptides.

Autor: Aleti G; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA., Kohn JN; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA., Troyer EA; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA., Weldon K; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA., Huang S; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA., Tripathi A; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA., Dorrestein PC; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.; Collaborative Mass Spectrometry Innovation Center, University of California San Diego, La Jolla, CA, 92093, USA., Swafford AD; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA., Knight R; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA., Hong S; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA. s1hong@health.ucsd.edu.; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. s1hong@health.ucsd.edu.
Jazyk: angličtina
Zdroj: BMC microbiology [BMC Microbiol] 2022 Mar 14; Vol. 22 (1), pp. 75. Date of Electronic Publication: 2022 Mar 14.
DOI: 10.1186/s12866-022-02483-4
Abstrakt: Background: Depression and obesity are highly prevalent, often co-occurring conditions marked by inflammation. Microbiome perturbations are implicated in obesity-inflammation-depression interrelationships, but how the microbiome mechanistically contributes to pathology remains unclear. Metabolomic investigations into microbial neuroactive metabolites may offer mechanistic insights into host-microbe interactions. Using 16S sequencing and untargeted mass spectrometry of saliva, and blood monocyte inflammation regulation assays, we identified key microbes, metabolites and host inflammation in association with depressive symptomatology, obesity, and depressive symptomatology-obesity comorbidity.
Results: Gram-negative bacteria with inflammation potential were enriched relative to Gram-positive bacteria in comorbid obesity-depression, supporting the inflammation-oral microbiome link in obesity-depression interrelationships. Oral microbiome was more highly predictive of depressive symptomatology-obesity co-occurrences than of obesity or depressive symptomatology independently, suggesting specific microbial signatures associated with obesity-depression co-occurrences. Mass spectrometry analysis revealed significant changes in levels of signaling molecules of microbiota, microbial or dietary derived signaling peptides and aromatic amino acids among depressive symptomatology, obesity and comorbid obesity-depression. Furthermore, integration of the microbiome and metabolomics data revealed that key oral microbes, many previously shown to have neuroactive potential, co-occurred with potential neuropeptides and biosynthetic precursors of the neurotransmitters dopamine, epinephrine and serotonin.
Conclusions: Together, our findings offer novel insights into oral microbial-brain connection and potential neuroactive metabolites involved.
(© 2022. The Author(s).)
Databáze: MEDLINE
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