The Immunogenetics of Autoimmune Blistering Diseases.
| Autor: | Kneiber D; Department of Dermatology, University of Illinois at Chicago, Chicago, USA., Kowalski EH; Department of Dermatology, University of Illinois at Chicago, Chicago, USA., Amber KT; Division of Dermatology, Rush University Medical Center, Chicago, USA. kyle_amber@rush.edu.; Department of Internal Medicine, Rush University Medical Center, Chicago, USA. kyle_amber@rush.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in experimental medicine and biology [Adv Exp Med Biol] 2022; Vol. 1367, pp. 173-212. |
| DOI: | 10.1007/978-3-030-92616-8_8 |
| Abstrakt: | Dermatological conditions constituting the group of autoimmune blistering diseases (AIBD) are characterized by loss of immunotolerance and humoral, as well as cellular, autoimmune responses that result in the development of bullae and erosions on the skin and mucous membranes. AIBDs are broadly categorized into pemphigus and pemphigoid classes with several distinct subtypes amongst them. Advances in genetics have allowed for the study and identification of alleles, and even single nucleotide polymorphisms, that harbor increased susceptibility or confer protection for the development of these conditions. The focus of this chapter pertains to a comprehensive review of the known genetic associations with AIBDs, including HLA class I-III, as well as non-HLA genes and non-coding sequences that influence cellular processes and signaling pathways. (© 2022. Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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