Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives.
Autor: | Ahmed EY; Chemistry of Natural Compounds Department, National Research Centre, Pharmaceutical and Drug Industries Research Institute, Cairo, Egypt., Abdelhafez OM; Chemistry of Natural Compounds Department, National Research Centre, Pharmaceutical and Drug Industries Research Institute, Cairo, Egypt., Zaafar D; Pharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt., Serry AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt., Ahmed YH; Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt., El-Telbany RFA; Biochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt., Abd Elmageed ZY; Department of Pharmacology, Edward Via College of Osteopathic Medicine, University of Louisiana, Monroe, Michigan, USA., Ali HI; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, Texas, United States. |
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Jazyk: | angličtina |
Zdroj: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Jun; Vol. 355 (6), pp. e2100327. Date of Electronic Publication: 2022 Mar 14. |
DOI: | 10.1002/ardp.202100327 |
Abstrakt: | Two new series of coumarin and benzofuran derivatives were designed, synthesized, and assessed for their in vitro and in vivo antitumor activities against breast cancer. Compounds 8, 9, 14, 15, and 17 exhibited the best antiproliferative activities (IC (© 2022 Deutsche Pharmazeutische Gesellschaft.) |
Databáze: | MEDLINE |
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