| Autor: |
Pejcic AV; Faculty of Medical Sciences, Department of Pharmacology and toxicology, University of Kragujevac, Kragujevac, Serbia., Milosavljevic MN; Faculty of Medical Sciences, Department of Pharmacology and toxicology, University of Kragujevac, Kragujevac, Serbia., Folic M; Faculty of Medical Sciences, Department of Pharmacy, University of Kragujevac, Kragujevac, Serbia.; Clinical Pharmacology Department, University Clinical Centre Kragujevac, Kragujevac, Serbia., Fernandes D; University of Minho, Braga, Portugal., Bentes J; Federal University of Roraima, Boa Vista, Brazil., Djesevic M; Department of Cardiology, Private Policlinic Center Eurofar Sarajevo, Sarajevo, Bosnia and Herzegovina., Jankovic S; Faculty of Medical Sciences, Department of Pharmacology and toxicology, University of Kragujevac, Kragujevac, Serbia.; Clinical Pharmacology Department, University Clinical Centre Kragujevac, Kragujevac, Serbia. |
| Abstrakt: |
Our aim was to explore and summarize available cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) suspected to be associated with amoxicillin reported in the literature. Electronic searches were conducted in several databases. Fifty-one publications describing a total of 64 patients who satisfied inclusion criteria were included in the review. The age of the patients ranged from 1.5-80 years (median: 24.5 years). TEN, SJS and SJS/TEN overlap were diagnosed in 30 (46.9%), 28 (43.8%) and 1 (1.6%) patients, respectively. SJS/TEN may occur promptly after administration of amoxicillin, but it could also be a delayed adverse effect. The total length of hospital stay ranged from 3-70 days (median: 16 days). Amoxicillin-induced SJS/TEN is accompanied by frequent occurrence of serious complications, long-term ocular and skin sequelae and high mortality rate. Clinicians should be aware that amoxicillin alone or combined with clavulanic acid can cause SJS/TEN in patients of all ages. |
