Blunted short-term autonomic cardiovascular reactivity to orthostatic and clinostatic challenges in fibromyalgia as an indicator of the severity of chronic pain.

Autor: Contreras-Merino AM; Department of Psychology, University of Jaén, Jaén, Spain. Electronic address: acmerino@ujaen.es., Davydov DM; Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow, Russia; University of Jaén Hospital, Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental (FIBAO), Jaén, Spain., Galvez-Sánchez CM; Department of Psychology, University of Jaén, Jaén, Spain., Reyes Del Paso GA; Department of Psychology, University of Jaén, Jaén, Spain.
Jazyk: angličtina
Zdroj: International journal of psychophysiology : official journal of the International Organization of Psychophysiology [Int J Psychophysiol] 2022 May; Vol. 175, pp. 61-70. Date of Electronic Publication: 2022 Mar 11.
DOI: 10.1016/j.ijpsycho.2022.03.001
Abstrakt: Fibromyalgia is a long-term pain disorder that has been related to autonomic dysfunctions and reduced cardiovascular reactivity. We aimed to assess the dynamic short-term cardiovascular responses to postural changes in fibromyalgia. Thirty-eight women with fibromyalgia and thirty-six healthy women underwent the "Chronic Pain Autonomic Stress Test". Electrocardiogram, blood pressure and impedance cardiography were continuously recorded during active standing and lying down. Second-by-second values were derived over the first 30 s of each posture. Lower reactivity during the beginning of each position was observed in fibromyalgia sufferers compared to healthy women, with smaller responses seen during stand up in heart rate, blood pressure, cardiac output, total peripheral resistance, and pre-ejection period, and smaller changes during lying down in heart rate, cardiac output and total peripheral resistance. The magnitude of the autonomic adjustments to postural changes was inversely associated with the severity of clinical pain. These findings indicate an early impaired autonomic cardiovascular response to orthostatic and clinostatic challenges in fibromyalgia, suggesting less autonomic flexibility and adaptability to situational demands and challenges. Short-term second-by-second cardiovascular measures may be useful in the clinical assessment of fibromyalgia.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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