Intraocular accommodative movements in monkeys; relationship to presbyopia.

Autor: Croft MA; Department of Ophthalmology and Visual Sciences, Madison, WI, 53792, USA. Electronic address: macroft@wisc.edu., Nork TM; Department of Ophthalmology and Visual Sciences, Madison, WI, 53792, USA., Heatley G; Department of Ophthalmology and Visual Sciences, Madison, WI, 53792, USA., Mcdonald JP; Department of Ophthalmology and Visual Sciences, Madison, WI, 53792, USA., Katz A; Department of Ophthalmology and Visual Sciences, Madison, WI, 53792, USA., Kaufman PL; Department of Ophthalmology and Visual Sciences, Madison, WI, 53792, USA; Wisconsin National Primate Research Center, Madison, WI, 53792, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Jazyk: angličtina
Zdroj: Experimental eye research [Exp Eye Res] 2022 Sep; Vol. 222, pp. 109029. Date of Electronic Publication: 2022 Mar 11.
DOI: 10.1016/j.exer.2022.109029
Abstrakt: Our goal was to quantify the age-related changes in the dynamic accommodative movements of the vitreous and aqueous humor in iridic, aniridic, phakic and aphakic primate eyes. Six bilaterally iridic and four bilaterally iridectomized rhesus monkeys, ranging in age from 6 to 25 years, received a stimulating electrode in the midbrain Edinger-Westphal nucleus to induce accommodation, measured by a Hartinger coincidence refractometer. One of the four iridectomized monkeys underwent unilateral extracapsular and another monkey underwent intracapsular lens extraction. Eyes were imaged utilizing specialized techniques and contrast agents to resolve intraocular structures. During accommodation the anterior hyaloid membrane and the posterior lens capsule bowed backward. Central vitreous fluid and structures/strands moved posteriorly toward the optic nerve region as peripheral vitreous, attached to the vitreous zonule, was pulled forward by ciliary muscle contraction. Triamcinolone particles injected intravitreally were also observed in the anterior chamber and moved from the anterior chamber toward the cleft of the anterior hyaloid membrane and then further posteriorly into the vitreous-filled cleft between the vitreous zonule and the ciliary body pars plana. These accommodative movements occurred in all eyes, and declined with age. There are statistically significant accommodative movements of various intravitreal structures. The posterior/anterior fluid flow between the anterior chamber and the vitreous compartments during accommodation/disaccommodation represents fluid displacement to allow/facilitate lens thickening. The posterior accommodative movement of central vitreous fluid may result from centripetal compression of the anterior tips of the cistern-like structure attached to the vitreous zonule, and posterior displacement of the central trunk of the cistern during ciliary muscle contraction and centripetal muscle movement. The findings may have implications for presbyopia.
Competing Interests: Declaration of competing interest None. Other commercial relationships unrelated to the work in this paper: CR: MaryAnn Croft: Commercial Relationship(s); Novartis Code C,F (consultant, Financial Support); Bridge Labs:Code R (Recipient) | Paul Kaufman: Commercial Relationship(s); Aerpio, Inc:Code C,H(Consultant, Honorarium); Allergan Pharm.:Code C,H; Applied Genetic Technology Corp:Code C, H; Bausch & Lomb:Code C,H; Chartwell:Code C; Elsevier R (Royalty); The Glaucoma Foundation Code C; Layer Bio Code C; Novartis Code C; OIC Code C; Singapore Eye Research Institute Code C,H; Trinity Partners Code C,H; Western Glaucoma Foundation Code C; RegenXBio Code C,H.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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