Possible vertical transmission of corona virus disease 19 (COVID-19) from infected pregnant mothers to neonates: a multicenter study.

Autor:	Almaghrabi R; Pediatric Department, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia., Shaiba LA; Pediatric Department, College of medicine, King Saud University, Riyadh, Saudi Arabia.; Neonatal Intensive Care Unit, King Saud University Medical City, Riyadh, Saudi Arabia., Babic I; Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia., Abdelbaky M; Registrar Obstetrics and Gynecology, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia., Aljuhani SI; Consultant of Obstetrics and Gynecologist, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia., Omer M; Registrar Neonatal Intensive Care Unit, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia., Abdelmaksoud HA; Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Abdulghani S; Department of Obstetrics and Gynecology, King Khalid University Medical City, Riyadh, Saudi Arabia.; Department of Pathology, King Saud University, Riyadh, Saudi Arabia., Hadid A; Pediatric Department, College of medicine, King Saud University, Riyadh, Saudi Arabia.; Neonatal Intensive Care Unit, King Saud University Medical City, Riyadh, Saudi Arabia., Arafah MA; Department of Pathology, King Saud University, Riyadh, Saudi Arabia., Omar Ali NM; Department of Pediatrics, College of Medicine, Majmaah University, Al Majma'ah, Saudi Arabia., Alamir A; Clinical Scientist, Molecular Microbiology, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia., Alateah S; Medical Laboratory Scientific Officer (MLSO), Riyadh, Saudi Arabia., Salem HAB; Medical Laboratory Scientific Officer (MLSO), Riyadh, Saudi Arabia.; Department of Pathology and Laboratory Medicine (Microbiology), College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia., Alrumaihi AM; Department of Pathology and Laboratory Medicine (Microbiology), College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia., Bukhari M; Department of Pathology, King Saud University, Riyadh, Saudi Arabia., Aljubab R; Department of Pathology, King Saud University, Riyadh, Saudi Arabia., AlSaud N; Pediatric Department, College of medicine, King Saud University, Riyadh, Saudi Arabia., Alhetheel AF; Department of Pathology and Laboratory Medicine (Microbiology), College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia., Somily AM; Department of Pathology and Laboratory Medicine (Microbiology), College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia., Albarrag AM; Department of Pathology and Laboratory Medicine (Microbiology), College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia., Alahdal HM; Department of Pediatric Infectious Disease, King Saud University Medical City, Riyadh, Saudi Arabia., Sonbol H; Biology Department, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Alnemri A; Pediatric Department, College of medicine, King Saud University, Riyadh, Saudi Arabia.; Neonatal Intensive Care Unit, King Saud University Medical City, Riyadh, Saudi Arabia., Alzamil F; Pediatric Department, College of medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Pediatric Infectious Disease, King Saud University Medical City, Riyadh, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 9558-9567. Date of Electronic Publication: 2022 Mar 13.
DOI:	10.1080/14767058.2022.2047926
Abstrakt:	Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious with various possible routes of transmission, resulting in high mortality globally. Controversy exists regarding the vertical transmission of the SARS-CoV-2 infection to fetuses of COVID-19-infected women. The aim of this study was to investigate the possibility of the vertical transmission of SARS-CoV-2 from COVID-19-infected mothers to their neonates. Materials and Methods: We prospectively collected demographical and clinical characteristics of 31 COVID-19 positive pregnant women and their neonates. All mothers and neonates were tested for SARS-CoV-2 infection using the real-time polymerase chain reaction on nasopharyngeal swabs and breast milk samples. Antenatal and placental abnormalities were ultrasonically and histopathologically examined. In cord blood samples, the immunoglobins (Ig) M and IgG were estimated qualitatively. Results: The women's mean age and gestational age were 31 years and 38 weeks, respectively, with 58% undergoing an elective cesarean section. Gestational diabetes was reported in 29% of cases, 64.5% of women were medically free and only 16.12% were symptomatic. A normal antenatal ultrasound was observed in 77.42% of cases. Nine cord blood samples were positive for IgG. Villous infarction (24%), villous agglutination, and chorangiosis (51%), accelerated villous maturation (21%) and reduced and hypercoiling were reported for 6.97% of the umbilical cords. Three newborns had possible vertical transmission of SARS-CoV-2 infection, of which, two were preterm and IUFD. The third neonate was born full-term, admitted to NICU and later discharged in good health. Conclusion: Our findings support the possibility of the direct vertical transmission of the SARS-CoV-2 infection to neonates from infected mothers. Further studies with a larger sample size are required to validate the current findings.
Databáze:	MEDLINE
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