Near-infrared spectroscopy predicts events in men and women: Results from the Lipid Rich Plaque study.

Autor: Mensink FB; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., Ten Cate TJF; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., Damen SAJ; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., Roes K; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., Di Mario C; Structural Interventional Cardiology, Department of Clinical & Experimental Medicine, Careggi University Hospital, Florence, Italy., Singh V; Department of Cardiology, Northwell Health, New York, NY, USA., Ali ZA; DeMatteis Cardiovascular Institute, St. Francis Hospital & Heart Center, Roslyn, NY, USA.; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA., Skinner W; Department of Cardiology, Central Baptist Hospital, Lexington, KY, USA., Artis A; Department of Cardiology, Methodist Hospital, Gary, IN, USA., Torguson R; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhang C; Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Doros G; Biostatistics Department, Boston University, Boston, MA, USA., Garcia-Garcia HM; Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Mintz GS; Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Geuns RV; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., Waksman R; Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
Jazyk: angličtina
Zdroj: International journal of cardiology. Heart & vasculature [Int J Cardiol Heart Vasc] 2022 Mar 08; Vol. 39, pp. 100985. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022).
DOI: 10.1016/j.ijcha.2022.100985
Abstrakt: Background: The Lipid Rich Plaque (LRP) study demonstrated that near-infrared spectroscopy imaging of non-obstructive lesions identified patients and segments at higher risk for subsequent non-culprit major adverse cardiac events (NC-MACE). Whether this is true for both men and women is not known. In this post hoc analysis of the LRP study, we sought to investigate whether the maximum 4-mm Lipid Core Burden Index (maxLCBI 4mm ) was of similar predictive value in men and women for NC-MACE.
Methods: Patients with an evaluable maxLCBI 4mm were stratified on the basis of sex at birth. A Cox proportional-hazards model was used to assess the predictive value of maxLCBI 4mm on future NC-MACE at the patient and plaque levels. The primary endpoint was cumulative incidence of NC-MACE at 24 months.
Results: Among 1271 patients, 388 (30.5%) were women. Women were older and had a higher cardiovascular risk profile. Cumulative incidence of NC-MACE at 24 months was 10.3% for women and 7.6% for men (log-rank p = 0.11). When comparing maxLCBI 4mm  > 400 to maxLCBI 4mm  ≤ 400, the hazard ratio (HR) for future NC-MACE was not significantly different between sexes: 2.10 (95% confidence interval [CI]: 1.28-3.44; p = 0.003) for men and 2.24 (95% CI: 1.18-4.28; p = 0.014) for women (p = 0.87). At the plaque level, the HR comparing maxLCBI 4mm  > 400 to maxLCBI 4mm  ≤ 400 was 3.49 (95% CI: 1.60-7.60, p = 0.002) for men and 4.79 (95% CI: 2.02-11.38, p < 0.001) for women, which was not significantly different (p = 0.57).
Conclusions: The maxLCBI 4mm was of similar predictive value for NC-MACE within 24 months in men and women.
(© 2022 The Authors. Published by Elsevier B.V.)
Databáze: MEDLINE
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