Safety of glucose-6 phosphate dehydrogenase deficient donors in living right lobe liver donation.
Autor: | Dogar AW; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Ullah K; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Ghaffar A; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Ud-Din S; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Hussain A; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Ahmed HB; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Abbas SH; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Ud-Din S; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Hamza MA; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Husnain A; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Shoaib A; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Ahmed B; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Raza H; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Zafar M; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Baig MA; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Qaiser MA; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Shahwani AU; Liver Transplant and Hepatobiliary Unit, Pir Abdul Qadir Shah Jelani Institute of Medical Sciences, Gambat, Sindh, Pakistan., Gupta S; Liver Transplant and Hepatobiliary, Max Super Speciality Hospital, Saket (Max Saket), New Delhi, India. |
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Jazyk: | angličtina |
Zdroj: | Clinical transplantation [Clin Transplant] 2022 Jun; Vol. 36 (6), pp. e14627. Date of Electronic Publication: 2022 Mar 13. |
DOI: | 10.1111/ctr.14627 |
Abstrakt: | Background: The literature lacks data on World Health Organization (WHO) class II and III deficient liver donors who underwent right hepatectomy during living donor liver transplantation (LDLT). Methods: In this prospective cohort study, we compared the perioperative outcomes of 15 glucose-6 phosphate dehydrogenase (G6PD) deficient living liver donors with a matched cohort of 39 nondeficient living liver donors undergoing right lobe donation. Results: Out of 15 G6PD deficient donors, four (26.67%) donors had class II, and 11 (73.34%) had class III G6PD deficiency. The mean postoperative trough hemoglobin level was significantly lower in the deficient group than the nondeficient group (9.38 ± 1.59 g/dL vs. 10.27 ± .91 g/dL, p = .046). The mean peak indirect bilirubin level was significantly higher in the deficient group than the nondeficient group (2.22 ± 1.38 mg/dL vs. 1.40 ± .89 mg/dL, p = .047), and a similar trend was observed in total serum bilirubin (3.99 ± 2.57 mg/dL vs. 2.99 ± 1.46 mg/dL, p = .038). Biochemical evidence of hemolysis was found only in three (20%) deficient donors, but none of them needed a blood transfusion. No mortality was observed in either group. All other parameters, including demographics, operative parameters, graft characteristics, and hospital stay were comparable between both groups (p > .05). Conclusion: G6PD deficiency with WHO class II and above should not be considered a contraindication for right lobe donation. (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
Databáze: | MEDLINE |
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