Versatile roles for histones in early development.

Autor: Shindo Y; Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. Electronic address: yuki.shindo@dartmouth.edu., Brown MG; Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA., Amodeo AA; Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. Electronic address: amanda.amodeo@dartmouth.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2022 Apr; Vol. 75, pp. 102069. Date of Electronic Publication: 2022 Mar 10.
DOI: 10.1016/j.ceb.2022.02.003
Abstrakt: The nuclear environment changes dramatically over the course of early development. Histones are core chromatin components that play critical roles in regulating gene expression and nuclear architecture. Additionally, the embryos of many species, including Drosophila, Zebrafish, and Xenopus use the availability of maternally deposited histones to time critical early embryonic events including cell cycle slowing and zygotic genome activation. Here, we review recent insights into how histones control early development. We first discuss the regulation of chromatin functions through interaction of histones and transcription factors, incorporation of variant histones, and histone post-translational modifications. We also highlight emerging roles for histones as developmental regulators independent of chromatin association.
Competing Interests: Conflict of interest statement Nothing declared.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: