Progress in traditional Chinese medicine and natural extracts for the treatment of lupus nephritis.

Autor: Wang YJ; Kidney Research Institute, Biomedical Big Data Center, West China Hospital, Sichuan University, 37GuoXue Alley, Chengdu 610041, Sichuan, China., Li YX; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., Li S; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., He W; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., Wang ZR; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., Zhan TP; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., Lv CY; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., Liu YP; The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu, China., Yang Y; Cancer Center, West China Hospital, Sichuan University, 37GuoXue Alley, Chengdu 610041, Sichuan, China., Zeng XX; Kidney Research Institute, Biomedical Big Data Center, West China Hospital, Sichuan University, 37GuoXue Alley, Chengdu 610041, Sichuan, China. Electronic address: zengxiaoxi@wchscu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 May; Vol. 149, pp. 112799. Date of Electronic Publication: 2022 Mar 09.
DOI: 10.1016/j.biopha.2022.112799
Abstrakt: Lupus nephritis (LN) is an autoimmune disease with multiple system involvement and is also one of the most serious forms of organ damage in systemic lupus erythematosus (SLE), which is mainly caused by the formation and deposition of immune complexes in glomeruli. More than 50% of SLE patients have clinical manifestations of renal damage. At present, the treatment of lupus nephritis is mainly based on glucocorticoids and immunosuppressants. However, due to adverse drug reactions and frequent recurrence or aggravation after drug reduction or withdrawal, the prognosis remains poor; thus, it is still one of the most important causes of end-stage renal failure. Therefore, new treatment strategies are urgently needed. This article aims to review the application of traditional Chinese medicine and natural extracts in the treatment of lupus nephritis to provide the basic mechanisms of treatment and a new treatment strategy with clear effects and high safety performance.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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