Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice.

Autor: Fu X; Neuroscience Program, Tulane University, New Orleans, LA, 70118, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA., Teboul E; Department of Neuroscience, Tufts University School of Medicine and Graduate School of Biomedical Sciences, Boston, MA, 02111, USA., Weiss GL; Department of Neuroscience, Tufts University School of Medicine and Graduate School of Biomedical Sciences, Boston, MA, 02111, USA., Antonoudiou P; Department of Neuroscience, Tufts University School of Medicine and Graduate School of Biomedical Sciences, Boston, MA, 02111, USA., Borkar CD; Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA.; Department of Psychology, Tulane University, New Orleans, LA, 70118, USA., Fadok JP; Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA.; Department of Psychology, Tulane University, New Orleans, LA, 70118, USA., Maguire J; Department of Neuroscience, Tufts University School of Medicine and Graduate School of Biomedical Sciences, Boston, MA, 02111, USA. jamie.maguire@tufts.edu., Tasker JG; Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA. tasker@tulane.edu.; Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA. tasker@tulane.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Mar 11; Vol. 13 (1), pp. 1290. Date of Electronic Publication: 2022 Mar 11.
DOI: 10.1038/s41467-022-28928-y
Abstrakt: Patterned coordination of network activity in the basolateral amygdala (BLA) is important for fear expression. Neuromodulatory systems play an essential role in regulating changes between behavioral states, however the mechanisms underlying this neuromodulatory control of transitions between brain and behavioral states remain largely unknown. We show that chemogenetic Gq activation and α1 adrenoreceptor activation in mouse BLA parvalbumin (PV) interneurons induces a previously undescribed, stereotyped phasic bursting in PV neurons and time-locked synchronized bursts of inhibitory postsynaptic currents and phasic firing in BLA principal neurons. This Gq-coupled receptor activation in PV neurons suppresses gamma oscillations in vivo and in an ex vivo slice model, and facilitates fear memory recall, which is consistent with BLA gamma suppression during conditioned fear expression. Thus, here we identify a neuromodulatory mechanism in PV inhibitory interneurons of the BLA which regulates BLA network oscillations and fear memory recall.
(© 2022. The Author(s).)
Databáze: MEDLINE
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