Introduction of Heated Cow's Milk Protein in Challenge-Proven Cow's Milk Allergic Children: The iAGE Study.

Autor:	de Jong NW; Department of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands.; Depertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., van Splunter ME; Department of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., Emons JAM; Depertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., Hettinga KA; Food Quality & Design Group, Wageningen University & Research Centre, 6708PB Wageningen, The Netherlands., Gerth van Wijk R; Department of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., Wichers HJ; Food Quality & Design Group, Wageningen University & Research Centre, 6708PB Wageningen, The Netherlands., Savelkoul HFJ; Cell Biology & Immunology Group, Wageningen University & Research Centre, 6708PB Wageningen, The Netherlands., Sprikkelman AB; Department of Peadiatric Pulmonology & Allergology, UMCG, University Medical Center Groningen, 9713GZ Groningen, The Netherlands.; University Medical Center Groningen, GRIAC Research Institute, University of Groningen, 9713GZ Groningen, The Netherlands., van Neerven RJJ; Cell Biology & Immunology Group, Wageningen University & Research Centre, 6708PB Wageningen, The Netherlands.; FrieslandCampina, 3811LP Amersfoort, The Netherlands., Liu L; Department of Rheumatoloy, Leiden University, 2311BD Leiden, The Netherlands., van der Meulen G; Department of Peadiatrics, Martini Hospital, 9728NT Groningen, The Netherlands., Herpertz I; Paediatric Allegology Center, VieCuri Medisch Centrum, 5912BL Venlo, The Netherlands., Duijvestijn YCM; Department of Peadiatrics, Noordwest Ziekenhuisgroep, 1815JD Alkmaar, The Netherlands., Breukels M; Deparment of Peadiatrics, Elkerliek, 5707HA Helmond, The Netherlands., Brouwer MI; Department of Peadiatrics, Canisius Wilhelmina Ziekenhuis, 6532SZ Nijmegen, The Netherlands., Schilperoord J; Department of Peadiatrics, OLVG Hospital, 1091AC Amsterdam, The Netherlands., van Doorn O; Department of Peadiatrics, OLVG Hospital, 1091AC Amsterdam, The Netherlands., Vlieg-Boerstra B; Department of Peadiatrics, OLVG Hospital, 1091AC Amsterdam, The Netherlands., van den Berg J; Department of Peadiatrics, Zuyderland MC, 6419PC Heerlen, The Netherlands., Pellis L; Ausnutria B.V., 8025BM Zwolle, The Netherlands., Terlouw S; Department of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., Hendriks AI; Depertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., Schreurs MWJ; Department of Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., van Boven FE; Department of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands., Arends NJT; Depertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015GD Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2022 Jan 31; Vol. 14 (3). Date of Electronic Publication: 2022 Jan 31.
DOI:	10.3390/nu14030629
Abstrakt:	The introduction of baked milk products in cow's milk (CM) allergic children has previously been shown to accelerate induction tolerance in a selected group of children. However, there is no standardized baked milk product on the market. Recently, a new standardized, heated and glycated cow's milk protein (HP) product was developed. The aim of this study was to measure safety and tolerability of a new, well characterized heated CM protein (HP) product in cow's milk allergic (CMA) children between the age of 3 and 36 months. The children were recruited from seven clinics throughout The Netherlands. The HP product was introduced in six incremental doses under clinical supervision. Symptoms were registered after introduction of the HP product. Several questionnaires were filled out by parents of the children. Skin prick tests were performed with CM and HP product, sIgE to CM and α-lactalbumin (Bos d4), β-lactoglobulin (Bos d5), serum albumin (Bos d 6), lactoferrin (Bos d7) and casein (Bos d8). Whereas 72% percent (18 out of 25) of the children tolerated the HP product, seven children experienced adverse events. Risk factors for intolerance to the HP product were higher skin prick test (SPT) histamine equivalent index (HEP) results with CM and the HP product, higher specific IgE levels against Bos d4 and Bos d8 levels and Bos d5 levels. In conclusion, the HP product was tolerated by 72% of the CM allergic children. Outcomes of SPT with CM and the HP product, as well as values of sIgE against caseins, α-lactalbumin, and β-lactoglobulin may predict the tolerability of the HP product. Larger studies are needed to confirm these conclusions.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu