Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and Liver Damage in Hypercholesterolemic Rats.

Autor: Lima Rocha JÉ; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Mendes Furtado M; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Mello Neto RS; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., da Silva Mendes AV; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Brito AKDS; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Sena de Almeida JOC; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Rodrigues Queiroz EI; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., de Sousa França JV; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Silva Primo MG; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Cunha Sales ALC; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Gomes Vasconcelos A; Research Center in Morphology and Applied Immunology, Faculty of Medicine, University of Brasília, Brasília 70910-900, Brazil., Felix Cabral W; Research Center in Morphology and Applied Immunology, Faculty of Medicine, University of Brasília, Brasília 70910-900, Brazil., Souza Kückelhaus SA; Research Center in Morphology and Applied Immunology, Faculty of Medicine, University of Brasília, Brasília 70910-900, Brazil., de Souza de Almeida Leite JR; Research Center in Morphology and Applied Immunology, Faculty of Medicine, University of Brasília, Brasília 70910-900, Brazil., Fortes Lustosa AKM; Galeno Farmácia de Manipulação, Virgínia Regina Fortes Castelo Branco e Cia Ltda, Teresina 64001-260, Brazil., Lucarini M; CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy., Durazzo A; CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy., Arcanjo DDR; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil., Martins MDCCE; Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2022 Jan 18; Vol. 14 (3). Date of Electronic Publication: 2022 Jan 18.
DOI: 10.3390/nu14030426
Abstrakt: Metabolic syndrome, especially its component related to dyslipidemia, is related to the development of nonalcoholic fatty liver disease (NAFLD), which is a disease with a significant global prevalence. Supplementation with omega-3 polyunsaturated fatty acids emerged as a complementary therapeutic possibility for dyslipidemia, but its benefits are questioned. This paper aims at evaluating the effects of fish oil supplementation in rats with hypercholesterolemia induced by hypercholesterolemic diet (HD). The study design is based on an experimental model in which the animals were randomly divided into 3 groups: G1 (standard commercial feed + saline solution); G2 (hypercholesterolemic diet + saline solution) and G3 (hypercholesterolemic diet + fish oil) over a period of 16 weeks. Metabolic control parameters and oxidative stress biomarkers were evaluated according to standardized methodologies. The G3 group showed significantly lower values of plasma concentrations of TG, and hepatic myeloperoxidase as well as higher erythrocyte superoxide dismutase activity (p < 0.05). Regarding histopathological analysis, there was lipid accumulation in the liver of animals from group G2; meanwhile, hepatocytes reorganization and expressive reduction of lipid vacuoles and hepatic TG content was observed in group G3. This study demonstrated how fish oil supplementation reduced the plasma concentration and hepatic content of triglycerides, as well as liver tissue damage in histopathological analysis.
Databáze: MEDLINE