Evaluation of an Ionic Calcium Fiber Supplement and Its Impact on Bone Health Preservation in a Dietary Calcium Deficiency Mice Model.

Autor: Herrera-Rodríguez SE; Unidad Sureste, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Km 5.5 Carretera, Sierra Papacal-Chuburná, Chuburná, Mérida 97302, Yucatán, Mexico., García-Márquez E; Unidad Noreste, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Autopista Mty-Aeropuerto, Vía de la Innovación 404, Parque PIIT, Cd Apodaca 66628, Nuevo León, Mexico., Padilla-Camberos E; Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Av. Normalistas 800, Colinas de La Normal, Guadalajara 44270, Jalisco, Mexico., Espinosa-Andrews H; Tecnología Alimentaria, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., CIATEJ, Cam. Arenero 1227, El Bajío, Zapopan 45019, Jalisco, Mexico.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2022 Jan 18; Vol. 14 (3). Date of Electronic Publication: 2022 Jan 18.
DOI: 10.3390/nu14030422
Abstrakt: Ionic calcium can help in the prevention of the process of osseous decalcification. This study aimed to evaluate the physicochemical properties and toxic effects of ionic calcium-fiber supplement ( ICa + ) and its impact on bone health preservation in mice C57/BL6 fed a calcium-deficient diet. Physicochemical properties include FTIR, apparent calcium solubility estimated by the calcium ratio obtained by ionization chromatography and atomic absorption. In vitro genotoxicity and cytotoxicity of the IC a + were assessed. Twenty-five 7-week-old C57/BL6 mice were fed calcium-free diet (CFD) or CFD plus CaCO 3 (1.33 mg Ca) or CFD plus ICa + (1.33-6.66 mg Ca) for six weeks. After that, bone mass and microstructure parameters were assessed. Histological staining was performed to determine calcium deposits. ICa + (100%) exhibited an apparent calcium solubility higher than CaCO 3 (12.3%). ICa + showed no cytotoxic and genotoxic in vitro activities. Histomorphometry analysis showed that the ICa + treated group displayed a higher trabecular number than the trabecular space. Also, the ratio BV/TV was increased compared with all treatments. Ionic calcium-fiber supplementation prevents bone deterioration compared to mice fed a calcium-deficient diet.
Databáze: MEDLINE
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