The use of optical coherence tomography angiography in comparing choriocapillaris recovery between two treatment strategies for multifocal choroiditis: a pilot clinical trial.

Autor: Agarwal A; Eye Institute, Cleveland Clinic Abu Dhabi, Al Maryah Island, Abu Dhabi, United Arab Emirates. aniruddha9@gmail.com., Abhaypal K; Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India., Aggarwal K; Ahalia Eye Care, Delma St, Airport Road, Abu Dhabi, United Arab Emirates., Erckens RJ; Maastricht University Medical Centre, University Eye Clinic Maastricht, Maastricht, The Netherlands., Berendschot TTJM; Maastricht University Medical Centre, University Eye Clinic Maastricht, Maastricht, The Netherlands., Webers CAB; Maastricht University Medical Centre, University Eye Clinic Maastricht, Maastricht, The Netherlands., Dogra M; Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India., Bansal R; Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India., Gupta V; Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Jazyk: angličtina
Zdroj: Journal of ophthalmic inflammation and infection [J Ophthalmic Inflamm Infect] 2022 Mar 11; Vol. 12 (1), pp. 12. Date of Electronic Publication: 2022 Mar 11.
DOI: 10.1186/s12348-022-00291-5
Abstrakt: Purpose: To compare differences in choriocapillaris flow deficit (CC FD) in multifocal choroiditis (MFC) between two treatment arms using optical coherence tomography angiography (OCTA).
Methods: In this prospective randomized clinical trial, patients were randomized to either Group 1 which received standard tapering dose of oral corticosteroids, or Group 2 which received additional dexamethasone implant (or intravitreal methotrexate). The patients were followed-up until 12 weeks using OCTA and other imaging tools. CC FD and visual acuity between the two groups were compared at each visit.
Results: Twenty-five subjects (17 males; 25 eyes) were studied (11 eyes in Group 1). There were no differences between the visual acuity or CC FD (1.12 versus 1.08 mm 2 ; p = 0.86) at baseline between the groups. However, patients in Group 2 achieved better visual acuity (0.32 ± 0.23 versus 0.15 ± 0.11; p = 0.025) and CC FD (0.54 versus 0.15 mm 2 ; p = 0.008) at 12 weeks.
Conclusions: OCTA is a useful tool in monitoring the CC FD recovery after treatment in MFC. Patients receiving intravitreal corticosteroid/methotrexate in addition to systemic corticosteroid showed greater resolution of CC FD on OCTA compared to those receiving only oral corticosteroids.
(© 2022. The Author(s).)
Databáze: MEDLINE
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