Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators.

Autor: Kyrchanova OV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. olna73@gmail.com., Postika NY; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia., Sokolov VV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia., Georgiev PG; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2022 Feb; Vol. 502 (1), pp. 21-24. Date of Electronic Publication: 2022 Mar 11.
DOI: 10.1134/S1607672922010069
Abstrakt: The segment-specific regulatory domains of the Bithorax complex (BX-C), which consists of three homeotic genes Ubx, abd-A and Abd-B, are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for higher eukaryotes. As was shown previously, the CTCF sites determine the insulator activity of the boundaries of the Abd-B regulatory region. In this study, it was shown that fragments of the Fab-3 and Fab-4 boundaries of the abd-A regulatory region, containing CTCF binding sites, are not effective insulators.
(© 2022. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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