Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells.

Autor: Desai P; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany., Rimal R; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany., Florea A; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.; Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX, Maastricht, The Netherlands., Gumerov RA; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.; Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation., Santi M; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany., Sorokina AS; Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation., Sahnoun SEM; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany., Fischer T; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany., Mottaghy FM; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany.; Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX, Maastricht, The Netherlands., Morgenroth A; Department of Nuclear Medicine, University Hospital RWTH Aachen, Pauwelstraße 30, 52074, Aachen, Germany., Mourran A; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany., Potemkin II; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.; Physics Department, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991, Moscow, Russian Federation.; National Research South Ural State University, Chelyabinsk, 454080, Russian Federation., Möller M; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany., Singh S; DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074, Aachen, Germany.; Max Planck Institute for Medical Research (MPImF), Jahnstrasse 29, 69120, Heidelberg, Germany.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 May 09; Vol. 61 (20), pp. e202116653. Date of Electronic Publication: 2022 Apr 07.
DOI: 10.1002/anie.202116653
Abstrakt: Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due to nephro- and hepato-toxicity, it is limited by its dosage. To amplify radiation damage to tumor cells, radiolabeled nanogels can be used. We show that by tuning the mechanical properties of nanogels significant enhancement in circulation half-life of the gel could be achieved. We demonstrate why and how small changes in the mechanical properties of the nanogels influence its cellular fate. Nanogels with a storage modulus of 37 kPa were minimally phagocytosed by monocytes and macrophages compared to nanogels with 93 kPa modulus. Using PET/CT a significant difference in the blood circulation time of the nanogels was shown. Computer simulations affirmed the results and predicted the mechanism of cellular uptake of the nanogels. Altogether, this work emphasizes the important role of elasticity even for particles that are inherently soft such as nano- or microgels.
(© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: