| Autor: |
Lazaropoulos MP; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA., Elrod JW; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Current opinion in physiology [Curr Opin Physiol] 2022 Feb; Vol. 25. Date of Electronic Publication: 2022 Feb 19. |
| DOI: |
10.1016/j.cophys.2022.100489 |
| Abstrakt: |
Adverse cardiac remodeling is often precipitated by chronic stress or injury inflicted upon the heart during the progression of cardiovascular diseases. Mitochondria play an important role in the cardiomyocyte response to stress by serving as a signaling hub for changes in cellular energetics, redox balance, contractile function, and cell death. Cardiac remodeling involves alterations to mitochondrial form and function that are either compensatory to maintain contractility or maladaptive, which promotes heart failure progression. In this mini-review, we focus on three mitochondrial processes that contribution to cardiac remodeling: Ca 2+ signaling, mitochondrial dynamics, and mitochondrial metabolism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect