A prevalence study in Guadalajara, Mexico, comparing tuberculin skin test and QuantiFERON-TB Gold In-Tube.

Autor: Plascencia Hernández A; University Center for Health Sciences (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, México.; 'Fray Antonio Alcalde' Civil Hospital of Guadalajara, Guadalajara, México., González Sánchez RM; University Center for Health Sciences (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, México.; 'Fray Antonio Alcalde' Civil Hospital of Guadalajara, Guadalajara, México., Hernández Cañaveral II; University Center for Health Sciences (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, México., Luévanos Velázquez A; University Center for Health Sciences (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, México.; 'Fray Antonio Alcalde' Civil Hospital of Guadalajara, Guadalajara, México., Martínez Arce PA; University Center for Health Sciences (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, México.; 'Fray Antonio Alcalde' Civil Hospital of Guadalajara, Guadalajara, México., González Díaz A; Pedro Kouri Institute of Tropical Medicine, Havana, Cuba., Sandoval Díaz M; Secretariat of Health, Guadalajara, Jalisco, Mexico., de Armas Rodríguez Y; Pedro Kouri Institute of Tropical Medicine, Havana, Cuba., González Ochoa E; Pedro Kouri Institute of Tropical Medicine, Havana, Cuba., Pérez Gómez HR; University Center for Health Sciences (Centro Universitario de Ciencias de la Salud), University of Guadalajara, Guadalajara, México.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Mar 10; Vol. 17 (3), pp. e0264982. Date of Electronic Publication: 2022 Mar 10 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0264982
Abstrakt: Background: Tuberculosis (TB) is a prevalent disease throughout the world. The extent of TB illness in childhood is not clear; recent data shows that 10-20% of the cases are found in children under 15 years old. In 2017, 1 million children developed the disease, of which 9% were co-infected with HIV.
Methods: A cross-sectional study that analyzed 48 children diagnosed with HIV-infection in Guadalajara, Mexico. The tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube test (QFT) were performed and compared to diagnose latent TB infection (LTBI).
Results: The average age was 9 years old (± 4), with an age range of 1-16 years; the 6-12-year-old group predominated with 50% of cases. 27 patients (56%) were male; 83% had received the BCG vaccination and 23% had a history of being contacts of TB cases. In the study, 40 patients (83%) were without immunosuppression; seven (15%) with moderate immunosuppression, and only one patient had severe immunodeficiency. Overall, 3 of the 48 children (6.2%) had a positive TST, while 8 out of 48 (16.6%) had a positive QFT. The concordance between the two tests was 89.6% (43/48) with Kappa = 0.5 (95% CI, 0.14-0.85).
Conclusions: The QFT test represents an opportunity in the diagnosis of LTBI, particularly in pediatric HIV- patients. This is the first study that compares the two tests (TST and QFT) in children with HIV-infection in Guadalajara, Mexico.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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