Biomaterials Based on Carbon Nanotube Nanocomposites of Poly(styrene- b -isobutylene- b -styrene): The Effect of Nanotube Content on the Mechanical Properties, Biocompatibility and Hemocompatibility.

Autor: Rezvova MA; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Nikishau PA; Research Institute for Physical Chemical Problems, Belarusian State University, 220006 Minsk, Belarus., Makarevich MI; Research Institute for Physical Chemical Problems, Belarusian State University, 220006 Minsk, Belarus.; Department of Chemistry, Belarusian State University, 220006 Minsk, Belarus., Glushkova TV; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Klyshnikov KY; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Akentieva TN; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Efimova OS; Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry SB RAS, 650000 Kemerovo, Russia., Nikitin AP; Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry SB RAS, 650000 Kemerovo, Russia., Malysheva VY; Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry SB RAS, 650000 Kemerovo, Russia., Matveeva VG; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Senokosova EA; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Khanova MY; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Danilov VV; Research Laboratory for Processing and Analysis of Big Data, Tomsk Polytechnic University, 634050 Tomsk, Russia., Russakov DM; Institute of Fundamental Sciences, Kemerovo State University, 650000 Kemerovo, Russia., Ismagilov ZR; Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry SB RAS, 650000 Kemerovo, Russia., Kostjuk SV; Research Institute for Physical Chemical Problems, Belarusian State University, 220006 Minsk, Belarus.; Department of Chemistry, Belarusian State University, 220006 Minsk, Belarus.; Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Ovcharenko EA; Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia.
Jazyk: angličtina
Zdroj: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Feb 22; Vol. 12 (5). Date of Electronic Publication: 2022 Feb 22.
DOI: 10.3390/nano12050733
Abstrakt: Nanocomposites based on poly(styrene- block -isobutylene- block -styrene) (SIBS) and single-walled carbon nanotubes (CNTs) were prepared and characterized in terms of tensile strength as well as bio- and hemocompatibility. It was shown that modification of CNTs using dodecylamine (DDA), featured by a long non-polar alkane chain, provided much better dispersion of nanotubes in SIBS as compared to unmodified CNTs. As a result of such modification, the tensile strength of the nanocomposite based on SIBS with low molecular weight (M n = 40,000 g mol -1 ) containing 4% of functionalized CNTs was increased up to 5.51 ± 0.50 MPa in comparison with composites with unmodified CNTs (3.81 ± 0.11 MPa). However, the addition of CNTs had no significant effect on SIBS with high molecular weight (M n ~70,000 g mol -1 ) with ultimate tensile stress of pure polymer of 11.62 MPa and 14.45 MPa in case of its modification with 1 wt% of CNT-DDA. Enhanced biocompatibility of nanocomposites as compared to neat SIBS has been demonstrated in experiment with EA.hy 926 cells. However, the platelet aggregation observed at high CNT concentrations can cause thrombosis. Therefore, SIBS with higher molecular weight (M n ~70,000 g mol -1 ) reinforced by 1-2 wt% of CNTs is the most promising material for the development of cardiovascular implants such as heart valve prostheses.
Databáze: MEDLINE
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