Real-World Efficacy of Regdanvimab on Clinical Outcomes in Patients with Mild to Moderate COVID-19.

Autor: Kim T; Department of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, Korea., Joo DH; Department of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, Korea., Lee SW; Department of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, Korea., Lee J; Department of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, Korea., Lee SJ; Department of Statistics, Pusan National University, Busan 46241, Korea., Kang J; Department of Family Medicine, Kosin University Gospel Hospital, Busan 46241, Korea.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2022 Mar 04; Vol. 11 (5). Date of Electronic Publication: 2022 Mar 04.
DOI: 10.3390/jcm11051412
Abstrakt: Background: This study aims to evaluate the real-world effectiveness of regdanvimab on clinical outcomes in patients with mild to moderate coronavirus disease 2019 (COVID-19).
Methods: This retrospective observational study included 152 patients (89 received regdanvimab and 63 did not) diagnosed with mild to moderate COVID-19 between August 2021 and October 2021 and admitted to Armed Forces Goyang Hospital. We collected information on the use of regdanvimab, remdesivir, dexamethasone, and supplemental oxygen; symptom severity score (SSS); and laboratory test results. A linear mixed-effects model was used to test the effectiveness of regdanvimab usage on SSS and the results of laboratory tests. A multivariate logistic regression model was used to calculate the odds ratio (OR) for additional therapeutic options, such as remdesivir, dexamethasone, and supplemental oxygen.
Results: The patients who received regdanvimab were older, showed a higher rate of vaccination, and had a higher Charlson comorbidity index, initial body temperature, and percentages of pneumonia at admission. The use of regdanvimab showed no interactive effects on the SSS and laboratory findings. Older age, male sex, obesity, high initial body temperature, and the presence of pneumonia at admission were associated with increased ORs for the use of these additional treatments. The use of regdanvimab reduced the probability of requiring additional therapies such as remdesivir, dexamethasone, and oxygen supplementation by 90.3% (95% confidence interval (CI), 60.3-97.6), 85.8% (95% CI, 34.2-96.9), and 89.8% (95% CI, 48.3-98), respectively.
Conclusions: Regdanvimab usage was well tolerated and was associated with a decreased probability of requiring remdesivir, dexamethasone, and oxygen therapy. However, changes in SSS were not significantly different by the drug usage.
Databáze: MEDLINE
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