Engineering extracellular vesicles for Alzheimer's disease: An emerging cell-free approach for earlier diagnosis and treatment.

Autor:	Lazar SV; Department of Surgery, University of California, Davis, California, USA., Mor S; Department of Surgery, University of California, Davis, California, USA., Wang D; Department of Surgery, University of California, Davis, California, USA.; Department of Biomedical Engineering, University of California, Davis, California, USA., Goldbloom-Helzner L; Department of Surgery, University of California, Davis, California, USA.; Department of Biomedical Engineering, University of California, Davis, California, USA., Clark K; Department of Surgery, University of California, Davis, California, USA.; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, University of California, Davis, California, USA., Hao D; Department of Surgery, University of California, Davis, California, USA.; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, University of California, Davis, California, USA., Farmer DL; Department of Surgery, University of California, Davis, California, USA.; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, University of California, Davis, California, USA., Wang A; Department of Surgery, University of California, Davis, California, USA.; Department of Biomedical Engineering, University of California, Davis, California, USA.; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, University of California, Davis, California, USA.
Jazyk:	angličtina
Zdroj:	WIREs mechanisms of disease [WIREs Mech Dis] 2022 Mar; Vol. 14 (2), pp. e1541. Date of Electronic Publication: 2021 Oct 19.
DOI:	10.1002/wsbm.1541
Abstrakt:	Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting over five million people globally and has no established cure. Current AD-related treatments only alleviate cognitive and behavioral symptoms and do not address disease onset or progression, underlining the unmet need to create an effective, innovative AD therapeutic. Extracellular vesicles (EVs) have emerged as a new class of nanotherapeutics. These secreted, lipid-bound cellular signaling carriers show promise for potential clinical applications for neurodegenerative diseases like AD. Additionally, analyzing contents and characteristics of patient-derived EVs may address the unmet need for earlier AD diagnostic techniques, informing physicians of altered genetic expression or cellular communications specific to healthy and diseased physiological states. There are numerous recent advances in regenerative medicine using EVs and include bioengineering perspectives to modify EVs, target glial cells in neurodegenerative diseases like AD, and potentially use EVs to diagnose and treat AD earlier. This article is categorized under: Neurological Diseases > Biomedical Engineering Neurological Diseases > Molecular and Cellular Physiology Neurological Diseases > Stem Cells and Development. (© 2021 Wiley Periodicals LLC.)
Databáze:	MEDLINE
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