Risk Factors Associated With COVID-19 Symptoms and Potential Vertical Transmission During Pregnancy: A Retrospective Cohort Study.

Autor:	Peter B; Neonatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA., Ree N; Pathology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA., Ferrer K; Pathology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA., Younes L; Family Medicine, AMITA Health Saints Mary and Elizabeth Hospital, Chicago, USA., Lepe B; Maternal Child Services, AMITA Health Saints Mary and Elizabeth Hospital, Chicago, USA., Manhal K; Neonatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA., Mydam J; Neonatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Mar 06; Vol. 14 (3), pp. e22900. Date of Electronic Publication: 2022 Mar 06 (Print Publication: 2022).
DOI:	10.7759/cureus.22900
Abstrakt:	Objective The COVID-19 pandemic is of special concern for pregnant women. A growing body of evidence suggests the virus can have a deleterious impact upon outcomes related to birth and newborn health. There is a paucity of published research demonstrating the factors that influence disease severity among those who are pregnant, while a growing body of evidence demonstrates that vertical transmission occurs. Our study investigated the impact of maternal characteristics upon COVID-19 outcomes, as well as whether disease severity impacted pregnancy outcomes. Methods We conducted a retrospective cohort study of pregnant women with COVID-19 who were admitted to two public hospitals in our state between April-August, 2020. Pregnancy outcomes and clinical, laboratory, and placental data were collected. Results Thirty-four pregnant women tested positive for SARS-CoV-2. Among them, 55% (19/34) were symptomatic. Of those who were symptomatic, 68% (13/19) presented with fever and cough. Those with symptoms had a statistically significant higher pregestational mean body mass index (BMI) compared with asymptomatic women (35.7±7.9 vs 26.7±6.9, P =0.004). Screening of biochemical records demonstrated that symptomatic women had lower potassium levels compared with those who were asymptomatic (median: 3.70 mEq/L vs 4.30 mEq/L, P =0.009). The lowest potassium level (3.0 mEq/L) and one of the highest BMIs (42.4 kg/m 2 ) was observed in the only case of postpartum mortality among the symptomatic women. We did not observe any influence of maternal COVID-19 severity on placental histopathology/infant health or evidence of vertical transmission. Conclusion High pregestational BMI and lower potassium levels were associated with the presence of COVID-19 symptoms among pregnant women. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Peter et al.)
Databáze:	MEDLINE
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