A combined association of serum uric acid, alanine aminotransferase and waist circumference with non-alcoholic fatty liver disease: a community-based study.
| Autor: | Wang M; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China., Wang M; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China., Zhang R; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China., Zhang L; Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Ding Y; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China., Tang Z; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China., Fan H; Department of Information, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Wang H; Mofan West Road Community Health Service Center, Nanjing, Jiangsu, China., Zhang W; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Chen Y; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China., Wang J; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China. |
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| Jazyk: | angličtina |
| Zdroj: | PeerJ [PeerJ] 2022 Mar 04; Vol. 10, pp. e13022. Date of Electronic Publication: 2022 Mar 04 (Print Publication: 2022). |
| DOI: | 10.7717/peerj.13022 |
| Abstrakt: | Background: Increasing evidence has supported that serum uric acid (SUA), alanine aminotransferase (ALT) and waist circumference (WC) are associated with the occurrence of non-alcoholic fatty liver disease (NAFLD). However, the combined role of these factors in early screening of NAFLD has not been investigated. We aimed to de lineate this role in a community-based population. Methods: Binary logistic regression was used to explore the correlations of SUA, ALT and WC with NAFLD risk. The goodness of fit and discriminative ability of the model were evaluated by the Hosmer-Lemeshow test and area under the receiver operating characteristic curve (AUROC), respectively. Results: Logistic regression analysis indicated that elevated SUA (adjusted odds ratio (OR) = 2.44, 95% confidence interval (CI) [1.76-3.38]), ALT (adjusted OR = 4.98, 95% CI [3.41-7.27]) and WC (adjusted OR = 3.22, 95% CI [2.01-5.16]) were facilitating factors for incident NAFLD after fully adjusted for related confounders. In addition, the risk of NAFLD followed linear trend s with increasing levels of these three indicators (all P Conclusions: SUA, ALT and WC were all associated with NAFLD, independent of known risk factors. The simple model composed of these indicators showed good performance in the Chinese population, which may be applicable for appraisal of NAFLD risk in primary healthcare. Competing Interests: The authors declare that they have no competing interests. (© 2022 Wang et al.) |
| Databáze: | MEDLINE |
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