The role of FSH to AMH ratio in poor prognosis patients undergoing ICSI cycle

Autor: Gözükara İ; Department of Obstetrics and Gynecology, Prof. Dr. Turan Çetin Women’s Health and IVF Center, Adana, Turkey, Yılmaz N; Clinic of Infertility and Reproductive Medicine, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey, Ceran MU; Department of Obstetrics and Gynecology, Başkent University, Konya Application and Research Center, Konya, Turkey, Atalay E; Clinic of Infertility and Reproductive Medicine, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey, Kahyaoğlu İ; Clinic of Infertility and Reproductive Medicine, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey, Gülerman HC; Clinic of Infertility and Reproductive Medicine, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey, Engin-Üstün Y; Clinic of Obstetric and Gynecology, University of Health Sciences Turkey, Ankara Etlik Zübeyde Hanım Women’s Health Research Center, Ankara, Turkey
Jazyk: angličtina
Zdroj: Journal of the Turkish German Gynecological Association [J Turk Ger Gynecol Assoc] 2022 Sep 05; Vol. 23 (3), pp. 184-189. Date of Electronic Publication: 2022 Mar 10.
DOI: 10.4274/jtgga.galenos.2022.2021-9-19
Abstrakt: Objective: The objective of this study was to estimate the number of oocyte retrieval and cycle cancellation using follicle stimulating hormone (FSH) to anti-Mullerian hormone (AMH) ratio in poor prognosis patients undergoing intracytoplasmic sperm injection treatment.
Material and Methods: This retrospective study including fresh cycles was conducted in Zekai Tahir Burak Women’s Health Training and Research Hospital, between January 2015 and October 2018. Women aged between 24 and 44 years were recruited and the baseline serum hormone levels, FSH/AMH ratio, and the antral follicle count were recorded. Number of retrieved oocytes, metaphase-II oocytes, fertilised oocytes, and the number and grade of the embryos were also recorded.
Results: A total of 108 cycles, corresponding to 92 women with poor prognosis were eligible for analysis. The use of FSH/AMH ratio performed well in predicting retrieved oocyte count <5 with an area under the curve (AUC) of 0.82 [95% confidence interval (CI): 0.71-0.92]. A FSH/AMH ratio cut-off of 11.36 was set for the retrieval of <5 oocyte at oocyte pick-up (OPU) with 80% sensitivity and 87% specificity. The FSH/AMH cut-off value was 14.22 to differentiate cycle cancellation and no oocyte retrieval at OPU, with a sensitivity of 91% and a specificity of 44% (AUC of 0.71; 95% CI: 0.59-0.83). There was no correlation between FSH/AMH ratio and clinical pregnancy.
Conclusion: The assessment of this simple ratio at the beginning of the cycle may help clinicians better anticipate gonadotropin stimulation treatment and better counsel patients about cycle cancellation and the expected oocyte yield.
Databáze: MEDLINE
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