CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.

Autor: Peclat TR; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Thompson KL; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Warner GM; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Chini CCS; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida, USA., Tarragó MG; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Mazdeh DZ; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Zhang C; Calico Life Sciences LLC, South San Francisco, CA, USA., Zavala-Solorio J; Calico Life Sciences LLC, South San Francisco, CA, USA., Kolumam G; Calico Life Sciences LLC, South San Francisco, CA, USA., Liang Wong Y; Calico Life Sciences LLC, South San Francisco, CA, USA., Cohen RL; Calico Life Sciences LLC, South San Francisco, CA, USA., Chini EN; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Jazyk: angličtina
Zdroj: Aging cell [Aging Cell] 2022 Apr; Vol. 21 (4), pp. e13589. Date of Electronic Publication: 2022 Mar 08.
DOI: 10.1111/acel.13589
Abstrakt: Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals.
(© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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