Association between lipoprotein(a) concentrations and atherosclerotic cardiovascular disease risk in patients with familial hypercholesterolemia: an analysis from the HELLAS-FH.

Autor: Anagnostis P; Department of Endocrinology, Police Medical Centre of Thessaloniki, Thessaloniki, Greece., Rizos CV; Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece., Skoumas I; Cardiology Clinic, Hippokration General Hospital, Athens, Greece., Rallidis L; Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece., Tziomalos K; 1st Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece., Skalidis E; Cardiology Clinic, University General Hospital of Heraklion, Heraklion, Greece., Kotsis V; Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital Thessaloniki, Thessaloniki, Greece., Doumas M; 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece., Kolovou G; Cardiometabolic Center, Lipid Clinic, LA apheresis Unit, Metropolitan Hospital, Athens, Greece., Sfikas G; Department of Internal Medicine, 424 General Military Training Hospital, Thessaloniki, Greece., Garoufi A; Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Β' Pediatrics Clinic, General Children's Hospital 'Pan. & Aglaia Kyriakou', Athens, Greece., Lambadiari V; 2nd Propedeutic Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece., Dima I; Cardiology Clinic, Hippokration General Hospital, Athens, Greece., Kiouri E; Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece., Agapakis D; 1st Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.; Department of Internal Medicine, General Hospital of Goumenissa, Goumenissa, Greece., Zacharis E; Cardiology Clinic, University General Hospital of Heraklion, Heraklion, Greece., Antza C; Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital Thessaloniki, Thessaloniki, Greece., Kolovou V; Cardiometabolic Center, Lipid Clinic, LA apheresis Unit, Metropolitan Hospital, Athens, Greece., Koumaras C; Department of Internal Medicine, 424 General Military Training Hospital, Thessaloniki, Greece., Bantouvakis G; Cardiology Clinic, University General Hospital of Heraklion, Heraklion, Greece., Liamis G; Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece., Liberopoulos EN; Department of Endocrinology, Police Medical Centre of Thessaloniki, Thessaloniki, Greece. vaglimp@yahoo.com.; Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece. vaglimp@yahoo.com.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2022 May; Vol. 76 (2), pp. 324-330. Date of Electronic Publication: 2022 Mar 09.
DOI: 10.1007/s12020-022-03013-y
Abstrakt: Aims: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in the general population. However, such a role in patients with familial hypercholesterolemia (FH) is less documented. The purpose of this study was to evaluate the association between Lp(a) concentrations and ASCVD prevalence in adult patients with FH.
Methods: This was a cross-sectional study from the Hellenic Familial Hypercholesterolemia Registry (HELLAS-FH). Patients were categorized into 3 tertiles according to Lp(a) levels.
Results: A total of 541 adult patients (249 males) with possible/probable/definite FH heterozygous FH (HeFH) were included (mean age 48.5 ± 15.0 years at registration, 40.8 ± 15.9 years at diagnosis). Median (interquartile range) Lp(a) concentrations in the 1st, 2nd and 3rd Lp(a) tertile were 6.4 (3.0-9.7), 22.4 (16.0-29.1) and 77.0 (55.0-102.0) mg/dL, respectively. There was no difference in lipid profile across Lp(a) tertiles. The overall prevalence of ASCVD was 9.4% in the first, 16.1% in the second and 20.6% in the third tertile (p = 0.012 among tertiles). This was also the case for premature ASCVD, with prevalence rates of 8.5, 13.4 and 19.8%, respectively (p = 0.010 among tertiles). A trend for increasing prevalence of coronary artery disease (8.3, 12.2 and 16.1%, respectively; p = 0.076 among tertiles) was also observed. No difference in the prevalence of stroke and peripheral artery disease was found across tertiles.
Conclusions: Elevated Lp(a) concentrations are significantly associated with increased prevalence of ASCVD in patients with possible/probable/definite HeFH.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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