Immuno-phenotyping of Canadian beef cattle: adaptation of the high immune response methodology for utilization in beef cattle.

Autor:	Husseini N; Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Beard SC; Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Hodgins DC; Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Barnes C; Bennett Equine Veterinary Services, Cambridge, Ontario, N1T 1T1, Canada., Chik E; Swine Health Professionals Ltd., Steinbach, Manitoba, R5G 1M1, Canada., Mallard BA; Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Jazyk:	angličtina
Zdroj:	Translational animal science [Transl Anim Sci] 2022 Jan 27; Vol. 6 (1), pp. txac006. Date of Electronic Publication: 2022 Jan 27 (Print Publication: 2022).
DOI:	10.1093/tas/txac006
Abstrakt:	The high immune response (HIR) methodology measures the genetic performance of the adaptive immune system to identify and breed animals with balanced and robust immunity. The HIR methodology has previously been used in dairy and swine to reduce disease but has not been fully investigated in beef cattle. The first objective of the current study was to examine whether the HIR methodology as standardized for use in dairy cattle was appropriate for use in beef cattle. The second objective was to determine the earliest age for immune response phenotyping of beef calves. In this study, beef calves ( n = 295) of various ages, as well as mature beef cows ( n = 170) of mixed breeds, were immunized using test antigens to assess their antibody- (AMIR) and cell-mediated immune responses (CMIR). Heritability for AMIR and CMIR was estimated at 0.43 and 0.18, respectively. The HIR methodology was appropriate for use in beef cattle; beef calves as young as 2-3 wk of age were capable of mounting AMIR responses comparable with those seen historically in mature Holstein dairy cows. Three-week-old beef calves mounted CMIR responses comparable with those of Holstein cows, but 9-mo-old calves and mature beef cows had significantly higher CMIR responses than Holsteins. The HIR methodology can be used to measure both AMIR and CMIR in beef calves as young as 3 wk of age. (© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society of Animal Science.)
Databáze:	MEDLINE
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